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Income Taxes (Details) - USD ($) $ in Thousands |  | 12 Months Ended |
--- | --- | --- | ---
Jan. 01, 2023 | Dec. 31, 2024 | Dec. 31, 2023
Income Taxes [Line Items] |  |  |
Valuation allowance |  | $ 101,613 | $ 90,565
Unused net operating losses |  | 327,800 |
Net operating losses |  | 104,800 |
Indefinite life |  | 84,600 |
Net operating loss percentage | 80.00% |  |
Federal research and development tax credits |  | 20,664 | $ 18,684
Research and development costs |  | 28,000 |
Accumulated gross amount |  | 87,900 |
Federal income tax [Member] |  |  |
Income Taxes [Line Items] |  |  |
Unused net operating losses |  | 189,300 |
Net operating losses due to expire in 2026 [Member] |  |  |
Income Taxes [Line Items] |  |  |
Net operating losses |  | 3,900 |
Net operating losses expire in 2034 - 2037 [Member] |  |  |
Income Taxes [Line Items] |  |  |
Net operating losses |  | 15,000 |
Tax Year 2033 [Member] |  |  |
Income Taxes [Line Items] |  |  |
Federal research and development tax credits |  | 6,700 |
Tax Year 2037 [Member] | Orphan Drug Credits [Member] |  |  |
Income Taxes [Line Items] |  |  |
Federal research and development tax credits |  | $ 16,500 |

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- Definition Amount, before allocation of valuation allowance, of deferred tax asset attributable to deductible temporary difference from in-process research and development cost acquired in business combination or from joint venture formation or both. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 6 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482685/740-10-50-6 + Details
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- Definition Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to tax credits. Including, but not limited to, research credit, foreign tax credit, investment tax credit, and other tax credits. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 12A -Subparagraph (b)(1) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482685/740-10-50-12A Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 12A -Subparagraph (a)(5) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482685/740-10-50-12A Reference 3: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 12 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482685/740-10-50-12 Reference 4: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 235 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SX 210.4-08(h)(2)) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480678/235-10-S99-1 + Details
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