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Condensed Consolidated Statements of Operations (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2015
Sep. 30, 2014
Sep. 30, 2015
Sep. 30, 2014
Revenue:        
License and milestone revenue (includes $5,120, $3,506, $14,672 and $9,966 from a related party) $ 13,045 $ 9,027 $ 131,430 $ 106,175
Collaboration services and other revenue (includes $868, $890, $2,221 and $2,507 from a related party) 6,493 4,635 24,956 15,321
Total revenue 19,538 13,662 156,386 121,496
Operating expenses:        
Research and development 52,071 40,617 154,165 99,536
General and administrative 11,237 10,140 31,399 24,088
Total operating expenses 63,308 50,757 185,564 123,624
Loss from operations (43,770) (37,095) (29,178) (2,128)
Interest expense (2,758) (2,723) (8,278) (8,174)
Interest and other income, net 1,458 283 3,008 1,358
Loss before income taxes (45,070) (39,535) (34,448) (8,944)
Provision (benefit) from income taxes 28 0 (38) 0
Net loss $ (45,098) $ (39,535) $ (34,410) $ (8,944)
Net loss per basic and diluted share $ (0.74) $ (2.93) $ (0.57) $ (0.67)
Weighted average number of common shares used to calculate net loss per basic and diluted share 60,767 13,503 59,926 13,355