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Collaboration Agreements - Accounting for the Astellas Agreements - Additional Information 2 (Detail) - Astellas Agreement [Member] - USD ($) $ in Millions | 1 Months Ended | 12 Months Ended | 35 Months Ended | 45 Months Ended | 117 Months Ended
--- | --- | --- | --- | --- | ---
Apr. 30, 2006 | Jun. 30, 2005 | Dec. 31, 2015 | Feb. 28, 2009 | Feb. 28, 2009 | Dec. 31, 2015
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Upfront, non-contingent and time-based payments received |  |  |  |  | $ 360.1 |
Minimum [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Discount rate applied |  |  | 17.50% |  |  |
Maximum [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Discount rate applied |  |  | 20.00% |  |  |
Europe [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Upfront, non-contingent and time-based payments received |  |  |  | $ 320.0 |  |
Development costs |  |  |  |  |  | $ 124.1
Non-contingent performance period | 36 months |  |  |  |  |
Total potential milestones | $ 425.0 |  |  |  |  |
Europe [Member] | Clinical and Development Milestone [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Substantive milestones | 90.0 |  |  |  |  |
Europe [Member] | Regulatory Milestone [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Substantive milestones | 335.0 |  |  |  |  |
Europe [Member] | Marketing approval milestone [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Substantive milestones | $ 25.0 |  |  |  |  |
Japan [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Upfront, non-contingent and time-based payments received |  |  |  |  | $ 40.1 |
Total potential milestones |  | $ 132.5 |  |  |  |
Commercial sales milestone |  | 15.0 |  |  |  |
Japan [Member] | Clinical and Development Milestone [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Substantive milestones |  | 22.5 |  |  |  |
Japan [Member] | Regulatory Milestone [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Substantive milestones |  | $ 95.0 |  |  |  |

X
- Definition Represents the amount of fixed and determinable co-development payments included under the collaborative agreement as arrangement consideration. + References No definition available. + Details
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X
- Definition Represents the amount of milestone payments related to commercial sales under the collaborative agreement. + References No definition available. + Details
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X
- Definition The non-contingent performance period related to a deliverable under a collaboration agreement. + References No definition available. + Details
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X
- Definition Represents the total potential amount of milestone payments related to development, regulatory approval and commercial sales under the collaborative agreement. + References No definition available. + Details
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- Definition Represents the total amount of substantive milestones that could be earned upon the achievement of certain pre-determined events from the total potential amount of milestone payments under the collaborative agreement. + References No definition available. + Details
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- Definition Interest rate used to find the present value of an amount to be paid or received in the future as an input to measure fair value. For example, but not limited to, weighted average cost of capital (WACC), cost of capital, cost of equity and cost of debt. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (bbb) -URI http://asc.fasb.org/extlink&oid=36462937&loc=d3e19207-110258 + Details
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