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Balance Sheet Components - Schedule of Property and Equipment (Detail) - USD ($) $ in Thousands | Dec. 31, 2015 | Dec. 31, 2014
--- | --- | ---
Property and equipment, gross | $ 176,747 | $ 174,490
Less: accumulated depreciation | (47,727) | (42,319)
Property and equipment, net | 129,020 | 132,171
Laboratory Equipment [Member] |  |
Property and equipment, gross | 18,233 | 17,114
Computer Equipment [Member] |  |
Property and equipment, gross | 5,701 | 5,106
Furniture and Fixtures [Member] |  |
Property and equipment, gross | 5,361 | 5,082
Leasehold improvements [Member] |  |
Property and equipment, gross | 93,380 | 92,790
Building shell [Member] |  |
Property and equipment, gross | 53,879 | 53,879
Construction in progress [Member] |  |
Property and equipment, gross | $ 193 | $ 519

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