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Balance Sheet Components | 12 Months Ended
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Dec. 31, 2015
Organization Consolidation And Presentation Of Financial Statements [Abstract] |
Balance Sheet Components |
5. | Balance Sheet Components
Cash and Cash Equivalents Cash and cash equivalents consisted of the following (in thousands):
|  | December 31, |
|  | 2015 |  |  | 2014 |
Cash |  | $ | 75,685 |  |  | $ | 151,653 |
Money market funds |  |  | 77,639 |  |  |  | 13,802 |
Total cash and cash equivalents |  | $ | 153,324 |  |  | $ | 165,455 |
Property and Equipment Property and equipment consisted of the following (in thousands):
|  | December 31, |
|  | 2015 |  |  | 2014 |
Laboratory equipment |  | $ | 18,233 |  |  | $ | 17,114 |
Computer equipment |  |  | 5,701 |  |  |  | 5,106 |
Furniture and fixtures |  |  | 5,361 |  |  |  | 5,082 |
Leasehold improvements |  |  | 93,380 |  |  |  | 92,790 |
Building shell (Refer to Note 8) |  |  | 53,879 |  |  |  | 53,879 |
Construction in progress |  |  | 193 |  |  |  | 519 |
Total property and equipment |  | $ | 176,747 |  |  | $ | 174,490 |
Less: accumulated depreciation |  |  | (47,727 | ) |  |  | (42,319 | )
Property and equipment, net |  | $ | 129,020 |  |  | $ | 132,171 |
Depreciation expense for the years ended December 31, 2015, 2014 and 2013 was $5.7 million, $4.5 million, and $5.1 million, respectively. Investments All investments are classified as available-for-sale. The amortized cost, gross unrealized holding gains or losses, and fair value of the Company’s available-for-sale investments by major investments type are summarized in the tables below (in thousands):
|  | December 31, 2015 |
|  | Amortized Cost |  |  | Gross Unrealized Holding Gains |  |  | Gross Unrealized Holding Losses |  |  | Fair Value |
Corporate bonds |  | $ | 126,522 |  |  | $ | 54 |  |  | $ | (473 | ) |  | $ | 126,103 |
Certificate of deposits |  |  | 8,217 |  |  |  | — |  |  |  | (2 | ) |  |  | 8,215 |
Bond and mutual funds |  |  | 25,052 |  |  |  | — |  |  |  | — |  |  |  | 25,052 |
Equity investments |  |  | 126 |  |  |  | 71 |  |  |  | — |  |  |  | 197 |
Total investments |  | $ | 159,917 |  |  | $ | 125 |  |  | $ | (475 | ) |  | $ | 159,567 |
|  | December 31, 2014 |
|  | Amortized Cost |  |  | Gross Unrealized Holding Gains |  |  | Gross Unrealized Holding Losses |  |  | Fair Value |
Corporate bonds |  | $ | 158,692 |  |  | $ | 254 |  |  | $ | (514 | ) |  | $ | 158,432 |
Equity investments |  |  | 124 |  |  |  | 77 |  |  |  | — |  |  |  | 201 |
Total investments |  | $ | 158,816 |  |  | $ | 331 |  |  | $ | (514 | ) |  | $ | 158,633 |
The contractual maturities of available-for-sale investments were as follows (in thousands):
|  | December 31, |
|  | 2015 |
Within one year |  | $ | 12,797 |
After one year through four years |  |  | 121,521 |
Total debt investments |  |  | 134,318 |
Bond and mutual funds |  |  | 25,052 |
Equity investments |  |  | 197 |
Total investments |  |  | 159,567 |
Available-for-sale investments are reported at fair value and as such, their associated unrealized gains and losses are reported as a separate component of stockholders’ equity within accumulated other comprehensive income (loss). Accrued Liabilities Accrued liabilities consisted of the following (in thousands):
|  | December 31, |
|  | 2015 |  |  | 2014 |
Preclinical and clinical trial accruals |  | $ | 27,973 |  |  | $ | 25,418 |
Payroll and related accruals |  |  | 13,535 |  |  |  | 15,608 |
Professional services |  |  | 1,662 |  |  |  | 2,401 |
Other |  |  | 4,762 |  |  |  | 5,558 |
Total accrued liabilities |  | $ | 47,932 |  |  | $ | 48,985 |

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