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Collaboration Agreements - AstraZeneca Agreements - Additional Information 1 (Detail) - AstraZeneca Agreements [Member] - USD ($) $ in Millions |  |  | 3 Months Ended | 6 Months Ended | 12 Months Ended | 30 Months Ended
--- | --- | --- | --- | --- | --- | ---
Dec. 31, 2013 | Jul. 30, 2013 | Jun. 30, 2015 | Dec. 31, 2013 | Dec. 31, 2015 | Dec. 31, 2015
U.S./RoW [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Expected upfront, non-contingent and time-based payments |  | $ 374.0 |  |  |  |
Upfront, non-contingent and time-based payments received |  |  |  | $ 82.0 |  | $ 312.0
Contingent payment |  | 62.0 |  |  |  |
Development and regulatory approval milestones |  | 550.0 |  |  |  |
Commercial sales milestone |  | 325.0 |  |  |  |
Shared development costs |  | 233.0 |  |  |  |
Additional consideration based on net sales description |  |  |  |  | Low 20% range |
U.S./RoW [Member] | Development Milestones [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Receipt of development milestone payment |  |  | $ 15.0 |  |  |
China [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Upfront, non-contingent and time-based payments received | $ 16.2 |  |  |  |  |
Contingent payment |  | 20.0 |  |  |  |
Development and regulatory approval milestones |  | 161.0 |  |  |  |
Commercial sales milestone |  | 167.5 |  |  |  |
Proceeds from upfront payments |  | $ 28.2 |  |  |  |

X
- Definition The amount of additional consideration based on net sales of product as defined under a collaboration agreement. + References No definition available. + Details
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- Definition Represents the amount of milestone payments related to commercial sales under the collaborative agreement. + References No definition available. + Details
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- Definition Represents the amount of contingent payments provided for under the collaboration agreement. + References No definition available. + Details
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- Definition Represents the potential amount of milestone payments related to development and regulatory approval under the collaborative agreement. + References No definition available. + Details
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- Definition Development milestone payment received. + References No definition available. + Details
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- Definition Represents the total amount of expected non-contingent upfront payments included under the collaborative agreement as arrangement consideration. + References No definition available. + Details
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- Definition Represents the amount of fixed and determinable non-contingent upfront payments included under the collaborative agreement as arrangement consideration. + References No definition available. + Details
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- Definition Represents the amount of upfront payments included under the collaborative agreement as arrangement consideration. + References No definition available. + Details
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- Definition Represents the total amount of development costs that will be shared under collaborative agreement. + References No definition available. + Details
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- Definition Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. + References No definition available. + Details
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- Details
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- Details
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