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Collaboration Agreements - Astellas Agreements - Additional Information (Detail) - Astellas Agreement [Member] - USD ($)
$ in Millions
1 Months Ended 12 Months Ended 35 Months Ended 45 Months Ended
Apr. 30, 2006
Jun. 30, 2005
Dec. 31, 2015
Dec. 31, 2013
Dec. 31, 2012
Dec. 31, 2010
Feb. 28, 2009
Feb. 28, 2009
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                
Upfront, non-contingent and time-based payments received               $ 360.1
Japan [Member]                
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                
Upfront, non-contingent and time-based payments received               $ 40.1
Development and regulatory approval milestones   $ 117.5            
Commercial sales milestone   $ 15.0            
Additional consideration based on net sales description     Low 20% range          
Clinical development milestones       $ 12.5        
Europe [Member]                
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                
Upfront, non-contingent and time-based payments received             $ 320.0  
Development and regulatory approval milestones $ 425.0              
Additional consideration based on net sales description     Low 20% range          
Clinical development milestones         $ 50.0 $ 40.0    
Percentage of joint development costs committed to fund 50.00%