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Consolidated Statements of Operations - USD ($)
shares in Thousands, $ in Thousands
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Revenue:      
License and milestone revenue (includes $18,701, $14,453 and $22,326 from a related party) $ 148,093 $ 117,191 $ 94,961
Collaboration services and other revenue (includes $2,895, $3,535 and $3,335 from a related party) 32,735 20,410 7,209
Total revenue 180,828 137,601 102,170
Operating expenses:      
Research and development 214,089 150,794 85,710
General and administrative 44,364 36,909 24,409
Total operating expenses 258,453 187,703 110,119
Loss from operations (77,625) (50,102) (7,949)
Interest and other, net      
Interest expense (11,033) (11,108) (10,702)
Interest income and other, net 3,121 1,706 3,708
Total interest and other, net (7,912) (9,402) (6,994)
Loss before income taxes (85,537) (59,504) (14,943)
Provision for income taxes 242 0 0
Net loss $ (85,779) $ (59,504) $ (14,943)
Net loss per share - basic and diluted $ (1.42) $ (3.17) $ (1.13)
Weighted average number of common shares used to calculate net loss per share - basic and diluted 60,337 18,775 13,186