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Consolidated Statements of Operations (Parenthetical) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
License and milestone revenue from a related party $ 148,093 $ 117,191 $ 94,961
Collaboration services and other revenue from a related party 32,735 20,410 7,209
Astellas Agreement [Member]      
License and milestone revenue from a related party 18,701 14,453 22,326
Collaboration services and other revenue from a related party $ 2,895 $ 3,535 $ 3,335