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Condensed Consolidated Statements of Operations (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Revenue:    
License and milestone revenue (includes $3,231 and $4,692 from a related party) $ 19,738 $ 11,506
Collaboration services and other revenue (includes $344 and $634 from a related party) 8,544 4,792
Total revenue 28,282 16,298
Operating expenses:    
Research and development 43,650 50,539
General and administrative 11,417 10,482
Total operating expenses 55,067 61,021
Loss from operations (26,785) (44,723)
Interest and other, net    
Interest expense (2,777) (2,758)
Interest income and other, net 1,416 843
Total interest and other, net (1,361) (1,915)
Loss before income taxes (28,146) (46,638)
Benefit from income taxes (305) (271)
Net loss $ (27,841) $ (46,367)
Net loss per share - basic and diluted $ (0.45) $ (0.78)
Weighted average number of common shares used to calculate net loss per share - basic and diluted 62,184 59,197