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Stock-Based Compensation - Schedule of Assumptions used to Estimate Fair Value of Stock Options Granted and Employee Stock Purchase Plans (Detail) - $ / shares
3 Months Ended 6 Months Ended
Jun. 30, 2016
Jun. 30, 2015
Jun. 30, 2016
Jun. 30, 2015
Employee stock options [Member]        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Expected term (in years) 5 years 3 months 18 days 5 years 2 months 12 days 5 years 3 months 18 days 5 years 2 months 12 days
Expected volatility 72.00% 70.00% 70.00% 70.00%
Risk-free interest rate 1.30% 1.70% 1.40% 1.70%
Expected dividend yield 0.00% 0.00% 0.00% 0.00%
Weighted average estimated fair value $ 11.60 $ 12.27 $ 11.48 $ 16.68
Employee stock purchase plans [Member]        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Expected volatility, minimum 61.90% 58.50% 61.90% 58.50%
Expected volatility, maximum 80.70% 69.00% 80.70% 69.00%
Risk-free interest rate, minimum 0.20% 0.10% 0.20% 0.10%
Risk-free interest rate, maximum 0.90% 0.60% 0.90% 0.60%
Expected dividend yield 0.00% 0.00% 0.00% 0.00%
Weighted average estimated fair value $ 10.06 $ 13.06 $ 10.98 $ 13.17
Employee stock purchase plans [Member] | Minimum [Member]        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Expected term (in years) 6 months 4 months 24 days 6 months 4 months 24 days
Employee stock purchase plans [Member] | Maximum [Member]        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Expected term (in years) 2 years 2 years 2 years 2 years