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Related Party Transactions - Additional Information (Detail) - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2016	Jun. 30, 2015	Jun. 30, 2016	Jun. 30, 2015	Dec. 31, 2015
Related Party Transaction [Line Items]
Accounts receivable from related party	$ 13,365,000		$ 13,365,000		$ 4,455,000
Accrued liabilities to related parties	1,351,000		1,351,000		2,045,000
Goodwin Procter LLP [Member] | Intellectual Property [Member] | Maximum [Member]
Related Party Transaction [Line Items]
Payments for legal matters	100,000		100,000
Astellas [Member] | Collaborative Arrangement [Member]
Related Party Transaction [Line Items]
Revenue related to collaboration agreements	13,400,000	$ 5,600,000	17,100,000	$ 10,900,000
Expense related to collaboration agreements	1,400,000	$ 1,300,000	3,000,000	$ 4,400,000
Accounts receivable from related party	13,400,000		13,400,000		4,500,000
Accrued liabilities to related parties	$ 1,400,000		$ 1,400,000		$ 2,000,000

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- Definition

Amount of receivables arising from transactions with related parties due within one year or the normal operating cycle, if longer.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
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Carrying amount as of the balance sheet date of obligations due all related parties. For classified balance sheets, represents the current portion of such liabilities (due within one year or within the normal operating cycle if longer).

+ References

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The amount of cash paid for the settlement of litigation or for other legal issues during the period.

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Expenses recognized resulting from transactions (excluding transactions that are eliminated in consolidated or combined financial statements) with related party.

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Amount of revenue, fees and commissions earned from transactions between (a) a parent company and its subsidiaries; (b) subsidiaries of a common parent; (c) an entity and trusts for the benefit of employees, for example, but not limited to, pension and profit-sharing trusts that are managed by or under the trusteeship of the entity's management; (d) an entity and its principal, owners, management, or members of their immediate families; and (e) affiliates.

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