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Condensed Consolidated Statements of Operations (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2016	Jun. 30, 2015	Jun. 30, 2016	Jun. 30, 2015
Revenue:
License and milestone revenue (includes $13,043, $4,860, $16,356 and $9,552 from a related party)	$ 73,197	$ 106,879	$ 92,935	$ 118,385
Collaboration services and other revenue (includes $326, $719, $678 and $1,353 from a related party)	16,083	13,671	24,628	18,463
Total revenue	89,280	120,550	117,563	136,848
Operating expenses:
Research and development	52,392	51,555	96,041	102,094
General and administrative	10,376	9,680	21,794	20,162
Total operating expenses	62,768	61,235	117,835	122,256
Income (loss) from operations	26,512	59,315	(272)	14,592
Interest and other, net
Interest expense	(2,438)	(2,762)	(5,215)	(5,520)
Interest income and other, net	129	707	1,545	1,550
Total interest and other, net	(2,309)	(2,055)	(3,670)	(3,970)
Income (loss) before income taxes	24,203	57,260	(3,942)	10,622
Provision for (benefit from) income taxes	(113)	205	(418)	(66)
Net income (loss)	$ 24,316	$ 57,055	$ (3,524)	$ 10,688
Net income (loss) per share:
Basic	$ 0.39	$ 0.95	$ (0.06)	$ 0.18
Diluted	$ 0.35	$ 0.83	$ (0.06)	$ 0.15
Weighted average number of common shares used to calculate net income (loss) per share:
Basic	62,582	59,798	62,383	59,499
Diluted	69,022	68,752	62,383	69,354

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