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Related Party Transactions - Additional Information (Detail) - USD ($) | 3 Months Ended | 9 Months Ended |
--- | --- | --- | ---
Sep. 30, 2016 | Sep. 30, 2015 | Sep. 30, 2016 | Sep. 30, 2015 | Dec. 31, 2015
Related Party Transaction [Line Items] |  |  |  |  |
Accounts receivable from related party | $ 4,816,000 |  | $ 4,816,000 |  | $ 4,455,000
Accrued liabilities to related parties | 1,843,000 |  | 1,843,000 |  | 2,045,000
Goodwin Procter LLP [Member] | Intellectual Property [Member] | Maximum [Member] |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |
Payments for legal matters | 100,000 | $ 100,000 | 100,000 | $ 100,000 |
Astellas [Member] | Collaborative Arrangement [Member] |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |
Revenue related to collaboration agreements | 4,800,000 | 6,000,000 | 21,800,000 | 16,900,000 |
Expense related to collaboration agreements | 1,800,000 | $ 3,400,000 | 4,800,000 | $ 7,800,000 |
Accounts receivable from related party | 4,800,000 |  | 4,800,000 |  | 4,500,000
Accrued liabilities to related parties | $ 1,800,000 |  | $ 1,800,000 |  | $ 2,000,000

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- Definition Amount of receivables arising from transactions with related parties due within one year or the normal operating cycle, if longer. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.3(a)(2)) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 850 -SubTopic 10 -Section 50 -Paragraph 3 -URI http://asc.fasb.org/extlink&oid=6457730&loc=d3e39603-107864 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 235 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.4-08.(k)(1)) -URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 850 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (d) -URI http://asc.fasb.org/extlink&oid=6457730&loc=d3e39549-107864 Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 850 -SubTopic 10 -Section 50 -Paragraph 4 -URI http://asc.fasb.org/extlink&oid=6457730&loc=d3e39622-107864 + Details
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