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Stock-Based Compensation - Schedule of Assumptions used to Estimate Fair Value of Stock Options Granted and Purchases under 2014 Employee Share Purchase Plan (Detail) - $ / shares
3 Months Ended 9 Months Ended
Sep. 30, 2016
Sep. 30, 2015
Sep. 30, 2016
Sep. 30, 2015
Employee stock options [Member]        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Expected term (in years) 5 years 3 months 18 days 5 years 2 months 12 days 5 years 3 months 18 days 5 years 2 months 12 days
Expected volatility 73.00% 70.00% 70.00% 70.00%
Risk-free interest rate 1.20% 1.70% 1.40% 1.70%
Expected dividend yield 0.00% 0.00% 0.00% 0.00%
Weighted average estimated fair value $ 10.73 $ 13.47 $ 11.46 $ 16.21
2014 Employee Share Purchase Plan [Member]        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Expected volatility, minimum 63.70% 58.50% 61.90% 58.50%
Expected volatility, maximum 80.70% 69.00% 80.70% 69.00%
Risk-free interest rate, minimum 0.40% 0.10% 0.20% 0.10%
Risk-free interest rate, maximum 0.90% 0.60% 0.90% 0.60%
Expected dividend yield 0.00% 0.00% 0.00% 0.00%
Weighted average estimated fair value $ 9.04 $ 12.97 $ 10.27 $ 13.10
2014 Employee Share Purchase Plan [Member] | Minimum [Member]        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Expected term (in years) 6 months 4 months 24 days 6 months 4 months 24 days
2014 Employee Share Purchase Plan [Member] | Maximum [Member]        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Expected term (in years) 2 years 2 years 2 years 2 years