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Collaboration Agreements - Summary of Revenue Recognized under Agreement (Detail) - USD ($) $ in Thousands | 3 Months Ended | 12 Months Ended
--- | --- | ---
Jun. 30, 2016 | Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |  |
Total license and milestone revenue |  | $ 137,352 | $ 148,093 | $ 117,191
Collaboration services and other revenue from a related party |  | 42,225 | 32,735 | 20,410
Revenue recognized |  | 179,577 | 180,828 | 137,601
Europe [Member] |  |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |  |
Revenue recognized |  | 153,669 | 159,123 | 119,559
Astellas Agreement [Member] |  |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |  |
Total license and milestone revenue |  | 24,421 | 18,701 | 14,453
Collaboration services and other revenue from a related party |  | 1,357 | 2,895 | 3,535
Astellas Agreement [Member] | Japan [Member] |  |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |  |
License revenue |  | 3,465 | 1,024 | 518
Milestones revenue | $ 10,000 | 10,000 | 0 | 0
Total license and milestone revenue |  | 13,465 | 1,024 | 518
Collaboration services and other revenue from a related party |  | 166 | 198 | 356
Astellas Agreement [Member] | Europe [Member] |  |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |  |
License revenue |  | 10,956 | 17,677 | 13,935
Milestones revenue |  | 0 | 0 | 0
Total license and milestone revenue |  | 10,956 | 17,677 | 13,935
Collaboration services and other revenue from a related party |  | 1,191 | 2,697 | 3,179
AstraZeneca Agreements [Member] | China-single unit of accounting [Member] |  |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |  |
Revenue recognized |  | 0 | 0 | 0
AstraZeneca Agreements [Member] | U.S./RoW [Member] |  |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |  |
License revenue |  | 112,931 | 114,392 | 102,738
Milestones revenue |  | 0 | 15,000 | 0
Total license and milestone revenue |  | 112,931 | 129,392 | 102,738
Collaboration services and other revenue from a related party |  | $ 40,738 | $ 29,731 | $ 16,820

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- Definition Revenue recognized from co-development services, manufacturing of clinical supplies, committee services and information services and other revenue. + References No definition available. + Details
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- Definition Revenue from multiple-deliverable arrangements that include licensing fees and services revenue and the amount of consideration recognized during the period for milestones. Licensing revenue is consideration received from another party for the right to use, but not own, certain of the entity's intangible assets. Licensing arrangements include, but are not limited to, rights to use a patent, copyright, technology, manufacturing process, software or trademark. Licensing fees are generally, but not always, fixed as to amount and not dependent upon the revenue generated by the licensing party. An entity may receive licensing fees for licenses that also generate royalty payments to the entity. Services revenue may be derived by providing other, non-specified, services during the reporting period. + References No definition available. + Details
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- Definition Revenue from multiple-deliverable arrangements that include licensing fees and services revenue. Licensing revenue is consideration received from another party for the right to use, but not own, certain of the entity's intangible assets. Licensing arrangements include, but are not limited to, rights to use a patent, copyright, technology, manufacturing process, software or trademark. Licensing fees are generally, but not always, fixed as to amount and not dependent upon the revenue generated by the licensing party. An entity may receive licensing fees for licenses that also generate royalty payments to the entity. Services revenue may be derived by providing other, nonspecified, services during the reporting period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.1(d),(e)) -URI http://asc.fasb.org/extlink&oid=63488584&loc=d3e20235-122688 + Details
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- Definition The amount of consideration recognized during the period for the milestone or milestones. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 605 -SubTopic 28 -Section 50 -Paragraph 2 -Subparagraph (e) -URI http://asc.fasb.org/extlink&oid=68058744&loc=SL6892177-166501 + Details
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- Definition Amount of revenue recognized from goods sold, services rendered, insurance premiums, or other activities that constitute an earning process. Includes, but is not limited to, investment and interest income before deduction of interest expense when recognized as a component of revenue, and sales and trading gain (loss). + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.1) -URI http://asc.fasb.org/extlink&oid=63488584&loc=d3e20235-122688 + Details
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