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v3.6.0.2

Consolidated Statement of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Operating activities |  |  |
Net loss | $ (61,680) | $ (85,779) | $ (59,504)
Adjustments to reconcile net loss to net cash provided by / (used in) operating activities: |  |  |
Depreciation | 6,040 | 5,679 | 4,470
Amortization of premium on investments | 2,729 | 2,997 | 658
Loss on disposal of property and equipment | 0 | 98 | (10)
Stock-based compensation | 32,132 | 27,681 | 18,698
Tax benefit on unrealized gain on available-for-sale securities | (211) | 0 | 0
Realized gain on sales of available-for-sale securities | (37) | (203) | 0
Changes in operating assets and liabilities: |  |  |
Accounts receivable ($353, $578 and $979 from related party) | 4,957 | (1,952) | 4,041
Prepaid expenses and other current assets | 1,099 | 978 | (1,628)
Other assets | (136) | (420) | (795)
Accounts payable | (298) | 1,970 | 3,485
Accrued liabilities ($(430), $(2,549) and $1,828 from related party) | 2,965 | (2,126) | 18,878
Deferred revenue | 16,837 | 27,654 | 33,557
Lease financing liability | 814 | 627 | 814
Other long-term liabilities | 1,897 | 4,225 | (250)
Net cash provided by (used in) operating activities | 7,108 | (18,571) | 22,414
Investing activities |  |  |
Purchases of property and equipment | (1,252) | (1,977) | (8,118)
Proceeds from sale of property and equipment | 0 | 2 | 10
Purchases of available-for-sale securities | (9,041) | (41,736) | (144,727)
Proceeds from sales of available-for-sale securities | 4,298 | 15,342 | 0
Proceeds from maturities of available-for-sale securities | 12,617 | 22,501 | 45,546
Net cash provided by (used in) investing activities | 6,622 | (5,868) | (107,289)
Financing activities |  |  |
Repayments of lease liability | (403) | (403) | (403)
Proceeds from initial public offering, net of underwriting discounts and commission costs | 0 | 0 | 155,933
Proceeds from AstraZeneca private placement | 0 | 0 | 20,000
Cash paid for payroll taxes on restricted stock unit releases | (2,740) | (2,243) | 0
Proceeds from issuance of common stock | 9,881 | 14,992 | 1,697
Payments of deferred offering costs | 0 | 0 | (3,135)
Net cash provided by financing activities | 6,738 | 12,346 | 174,092
Effect of exchange rate change on cash and cash equivalents | (10) | (38) | (94)
Net increase (decrease) in cash and cash equivalents | 20,458 | (12,131) | 89,123
Total cash and cash equivalents at beginning of period | 153,324 | 165,455 | 76,332
Total cash and cash equivalents at end of period | 173,782 | 153,324 | 165,455
Supplemental cash flow information: |  |  |
Interest payments | 295 | 335 | 377
Balance in accounts payable and accrued liabilities related to purchases of property and equipment | 356 | 931 | 280
Deferred offering costs recorded in accounts payable and accrued liabilities | $ 0 | $ 0 | $ 974

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- Definition The cash outflow to acquire debt and equity securities not classified as either held-to-maturity securities or trading securities which would be classified as available-for-sale securities and reported at fair value, with unrealized gains and losses excluded from earnings and reported in a separate component of shareholders' equity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3213-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=66010992&loc=d3e26853-111562 + Details
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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3213-108585 + Details
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- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3255-108585 + Details
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- Definition The cash inflow associated with the amount received from entity's raising of capital via private rather than public placement. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3255-108585 + Details
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- Definition The cash inflow associated with maturities (principal being due), prepayments and calls (requests of early payments) on securities not classified as either held-to-maturity securities or trading securities which are classified as available-for-sale securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3179-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=66010992&loc=d3e26853-111562 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 + Details
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- Definition The cash inflow associated with the sale of debt and equity securities classified as available-for-sale securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=66010992&loc=d3e26853-111562 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3179-108585 + Details
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- Definition The cash inflow from the sale of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3179-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 + Details
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- Definition The cash outflow for the obligation for a lease meeting the criteria for capitalization (with maturities exceeding one year or beyond the operating cycle of the entity, if longer). + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3291-108585 + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3602-108585 + Details
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- References No definition available. + Details
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