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v3.6.0.2

Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Revenue: |  |  |
License and milestone revenue (includes $24,421, $18,701 and $14,453 from a related party) | $ 137,352 | $ 148,093 | $ 117,191
Collaboration services and other revenue (includes $1,357, $2,895 and $3,535 from a related party) | 42,225 | 32,735 | 20,410
Total revenue | 179,577 | 180,828 | 137,601
Operating expenses: |  |  |
Research and development | 187,206 | 214,089 | 150,794
General and administrative | 46,025 | 44,364 | 36,909
Total operating expenses | 233,231 | 258,453 | 187,703
Loss from operations | (53,654) | (77,625) | (50,102)
Interest and other, net |  |  |
Interest expense | (10,725) | (11,033) | (11,108)
Interest income and other, net | 2,628 | 3,121 | 1,706
Total interest and other, net | (8,097) | (7,912) | (9,402)
Loss before income taxes | (61,751) | (85,537) | (59,504)
Provision for (benefit from) income taxes | (71) | 242 | 0
Net loss | $ (61,680) | $ (85,779) | $ (59,504)
Net loss per share - basic and diluted | $ (0.98) | $ (1.42) | $ (3.17)
Weighted average number of common shares used to calculate net loss per share - basic and diluted | 62,744 | 60,337 | 18,775

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