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Balance Sheet Components (Tables) | 12 Months Ended
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Dec. 31, 2016
Organization Consolidation And Presentation Of Financial Statements [Abstract] |
Schedule of Cash and Cash Equivalents | Cash and cash equivalents consisted of the following (in thousands):
|  | December 31, |
|  | 2016 |  |  | 2015 |
Cash |  | $ | 79,239 |  |  | $ | 75,685 |
Money market funds |  |  | 94,543 |  |  |  | 77,639 |
Total cash and cash equivalents |  | $ | 173,782 |  |  | $ | 153,324 |
Schedule of Property and Equipment | Property and equipment consisted of the following (in thousands):
|  | December 31, |
|  | 2016 |  |  | 2015 |
Laboratory equipment |  | $ | 18,533 |  |  | $ | 18,233 |
Computer equipment |  |  | 5,678 |  |  |  | 5,701 |
Furniture and fixtures |  |  | 5,533 |  |  |  | 5,361 |
Leasehold improvements |  |  | 93,564 |  |  |  | 93,380 |
Building shell (Refer to Note 8) |  |  | 53,879 |  |  |  | 53,879 |
Construction in progress |  |  | 109 |  |  |  | 193 |
Total property and equipment |  | $ | 177,296 |  |  | $ | 176,747 |
Less: accumulated depreciation |  |  | (53,639 | ) |  |  | (47,727 | )
Property and equipment, net |  | $ | 123,657 |  |  | $ | 129,020 |
Summary of Amortized Cost, Gross Unrealized Holding Gains or Losses, and Fair Value of Available-for-Sale Investments | All investments are classified as available-for-sale. The amortized cost, gross unrealized holding gains or losses, and fair value of the Company’s available-for-sale investments by major investments type are summarized in the tables below (in thousands):
|  | December 31, 2016 |
|  | Amortized Cost |  |  | Gross Unrealized Holding Gains |  |  | Gross Unrealized Holding Losses |  |  | Fair Value |
Corporate bonds |  | $ | 126,550 |  |  | $ | 182 |  |  | $ | (49 | ) |  | $ | 126,683 |
Certificate of deposits |  |  | 1,037 |  |  |  | — |  |  |  | — |  |  |  | 1,037 |
Bond and mutual funds |  |  | 22,305 |  |  |  | 157 |  |  |  | — |  |  |  | 22,462 |
Equity investments |  |  | 125 |  |  |  | 100 |  |  |  | — |  |  |  | 225 |
Total investments |  | $ | 150,017 |  |  | $ | 439 |  |  | $ | (49 | ) |  | $ | 150,407 |
|  | December 31, 2015 |
|  | Amortized Cost |  |  | Gross Unrealized Holding Gains |  |  | Gross Unrealized Holding Losses |  |  | Fair Value |
Corporate bonds |  | $ | 126,522 |  |  | $ | 54 |  |  | $ | (473 | ) |  | $ | 126,103 |
Certificate of deposits |  |  | 8,217 |  |  |  | — |  |  |  | (2 | ) |  |  | 8,215 |
Bond and mutual funds |  |  | 25,052 |  |  |  | — |  |  |  | — |  |  |  | 25,052 |
Equity investments |  |  | 126 |  |  |  | 71 |  |  |  | — |  |  |  | 197 |
Total investments |  | $ | 159,917 |  |  | $ | 125 |  |  | $ | (475 | ) |  | $ | 159,567 |
Summary of Contractual Maturities Available-for-Sale Investments at Fair Value | The contractual maturities of available-for-sale investments were as follows (in thousands):
|  | December 31, 2016 |
Within one year |  | $ | 67,075 |
After one year through four years |  |  | 60,645 |
Total debt investments |  |  | 127,720 |
Bond and mutual funds |  |  | 22,462 |
Equity investments |  |  | 225 |
Total investments |  |  | 150,407 |
Schedule of Accrued Liabilities | Accrued liabilities consisted of the following (in thousands):
|  | December 31, |
|  | 2016 |  |  | 2015 |
Preclinical and clinical trial accruals |  | $ | 29,550 |  |  | $ | 27,973 |
Payroll and related accruals |  |  | 14,232 |  |  |  | 13,535 |
Professional services |  |  | 1,252 |  |  |  | 1,662 |
Other |  |  | 5,880 |  |  |  | 4,762 |
Total accrued liabilities |  | $ | 50,914 |  |  | $ | 47,932 |

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