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Summary of Significant Accounting Policies - Additional Information (Detail)
12 Months Ended
Dec. 31, 2016
USD ($)
Segment
Dec. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Dec. 31, 2013
USD ($)
Accounting Policy [Line Items]        
Number of operating segment | Segment 1      
Highly liquid investment maturity period three months or less      
Restricted time deposits $ 6,217,000 $ 7,254,000    
Cash and cash equivalents $ 173,782,000 153,324,000 $ 165,455,000 $ 76,332,000
Long term Investments Maturity 12 months      
Short term investments Maturity 12 months      
Impairment of long-lived assets $ 0      
Minimum [Member] | Computer Equipment [Member]        
Accounting Policy [Line Items]        
Property and equipment estimated useful life 3 years      
Minimum [Member] | Laboratory Equipment [Member]        
Accounting Policy [Line Items]        
Property and equipment estimated useful life 3 years      
Minimum [Member] | Furniture and Fixtures [Member]        
Accounting Policy [Line Items]        
Property and equipment estimated useful life 3 years      
Maximum [Member] | Computer Equipment [Member]        
Accounting Policy [Line Items]        
Property and equipment estimated useful life 5 years      
Maximum [Member] | Laboratory Equipment [Member]        
Accounting Policy [Line Items]        
Property and equipment estimated useful life 5 years      
Maximum [Member] | Furniture and Fixtures [Member]        
Accounting Policy [Line Items]        
Property and equipment estimated useful life 5 years      
Foreign subsidiaries [Member]        
Accounting Policy [Line Items]        
Cash and cash equivalents $ 24,300,000      
Reclassified from Cash Paid for Payroll Taxes on Restricted Stock Unit Releases to Gross Proceeds from Issuance of Common Stock [Member]        
Accounting Policy [Line Items]        
Prior period reclassification adjustment   $ 2,200,000 $ 0