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Consolidated Statements of Operations - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Revenue:      
License and milestone revenue (includes $24,421, $18,701 and $14,453 from a related party) $ 137,352 $ 148,093 $ 117,191
Collaboration services and other revenue (includes $1,357, $2,895 and $3,535 from a related party) 42,225 32,735 20,410
Total revenue 179,577 180,828 137,601
Operating expenses:      
Research and development 187,206 214,089 150,794
General and administrative 46,025 44,364 36,909
Total operating expenses 233,231 258,453 187,703
Loss from operations (53,654) (77,625) (50,102)
Interest and other, net      
Interest expense (10,725) (11,033) (11,108)
Interest income and other, net 2,628 3,121 1,706
Total interest and other, net (8,097) (7,912) (9,402)
Loss before income taxes (61,751) (85,537) (59,504)
Provision for (benefit from) income taxes (71) 242 0
Net loss $ (61,680) $ (85,779) $ (59,504)
Net loss per share - basic and diluted $ (0.98) $ (1.42) $ (3.17)
Weighted average number of common shares used to calculate net loss per share - basic and diluted 62,744 60,337 18,775