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Condensed Consolidated Statements of Operations (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016
Revenue:
License and milestone revenue (includes $4,278, $13,043, $7,527 and $16,356 from a related party)	$ 21,352	$ 73,197	$ 40,933	$ 92,935
Collaboration services and other revenue (includes $445, $326, $785 and $678 from a related party)	7,645	16,083	14,955	24,628
Total revenue	28,997	89,280	55,888	117,563
Operating expenses:
Research and development	46,981	52,392	93,713	96,041
General and administrative	13,425	10,376	24,955	21,794
Total operating expenses	60,406	62,768	118,668	117,835
Income (loss) from operations	(31,409)	26,512	(62,780)	(272)
Interest and other, net
Interest expense	(2,757)	(2,438)	(5,132)	(5,215)
Interest income and other, net	1,031	129	1,677	1,545
Total interest and other, net	(1,726)	(2,309)	(3,455)	(3,670)
Income (loss) before income taxes	(33,135)	24,203	(66,235)	(3,942)
Provision for (benefit from) income taxes	48	(113)	109	(418)
Net income (loss)	$ (33,183)	$ 24,316	$ (66,344)	$ (3,524)
Net income (loss) per share:
Basic	$ (0.48)	$ 0.39	$ (0.99)	$ (0.06)
Diluted	$ (0.48)	$ 0.35	$ (0.99)	$ (0.06)
Weighted average number of common shares used to calculate net income (loss) per share:
Basic	69,638	62,582	66,853	62,383
Diluted	69,638	69,022	66,853	62,383

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