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Condensed Consolidated Statements of Operations (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Sep. 30, 2017
Sep. 30, 2016
Revenue:        
License and milestone revenue (includes $4,125, $4,371, $11,652 and $20,727 from a related party) $ 19,997 $ 20,867 $ 60,930 $ 113,802
Collaboration services and other revenue (includes $445, $436, $1,230 and $1,114 from a related party) 7,275 9,235 22,230 33,863
Total revenue 27,272 30,102 83,160 147,665
Operating expenses:        
Research and development 50,336 40,558 144,049 136,599
General and administrative 12,953 11,646 37,908 33,440
Total operating expenses 63,289 52,204 181,957 170,039
Loss from operations (36,017) (22,102) (98,797) (22,374)
Interest and other, net        
Interest expense (2,769) (2,760) (7,901) (7,975)
Interest income and other, net 1,106 866 2,783 2,411
Total interest and other, net (1,663) (1,894) (5,118) (5,564)
Loss before income taxes (37,680) (23,996) (103,915) (27,938)
Provision for (benefit from) income taxes 57 158 166 (260)
Net loss $ (37,737) $ (24,154) $ (104,081) $ (27,678)
Net loss per share - basic and diluted $ (0.50) $ (0.38) $ (1.49) $ (0.44)
Weighted average number of common shares used to calculate net loss per share - basic and diluted 75,891 62,858 69,899 62,543