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Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Revenue: |  |  |
License and milestone revenue (includes $15,307, $24,421 and $18,701 from a related party) | $ 96,056 | $ 137,352 | $ 148,093
Collaboration services and other revenue (includes $1,578, $1,357 and $2,895 from a related party) | 29,612 | 42,225 | 32,735
Total revenue | 125,668 | 179,577 | 180,828
Operating expenses: |  |  |
Research and development | 196,517 | 187,206 | 214,089
General and administrative | 51,760 | 46,025 | 44,364
Total operating expenses | 248,277 | 233,231 | 258,453
Loss from operations | (122,609) | (53,654) | (77,625)
Interest and other, net |  |  |
Interest expense | (9,706) | (10,725) | (11,033)
Interest income and other, net | 6,433 | 2,628 | 3,121
Total interest and other, net | (3,273) | (8,097) | (7,912)
Loss before income taxes | (125,882) | (61,751) | (85,537)
Provision for (benefit from) income taxes | 321 | (71) | 242
Net loss | $ (126,203) | $ (61,680) | $ (85,779)
Net loss per share - basic and diluted | $ (1.73) | $ (0.98) | $ (1.42)
Weighted average number of common shares used to calculate net loss per share - basic and diluted | 72,987 | 62,744 | 60,337

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- Definition The amount of net income or loss for the period per each share in instances when basic and diluted earnings per share are the same amount and reported as a single line item on the face of the financial statements. Basic earnings per share is the amount of net income or loss for the period per each share of common stock or unit outstanding during the reporting period. Diluted earnings per share includes the amount of net income or loss for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period. + References No definition available. + Details
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