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v3.8.0.1

Consolidated Statement of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Operating activities |  |  |
Net loss | $ (126,203) | $ (61,680) | $ (85,779)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities: |  |  |
Depreciation | 6,099 | 6,040 | 5,679
Amortization of premium on investments | 1,844 | 2,729 | 2,997
Unrealized loss (gain) on short-term investments | 2 | 0 | 0
Gain on disposal of property and equipment | 3 | 0 | 98
Stock-based compensation | 37,539 | 32,132 | 27,681
Tax benefit on unrealized gain on available-for-sale securities | 0 | (211) | 0
Realized gain on sales of available-for-sale securities | (143) | (37) | (203)
Changes in operating assets and liabilities: |  |  |
Accounts receivable ($98, $353 and $578 from related party) | 1,996 | 4,957 | (1,952)
Prepaid expenses and other current assets | (1,911) | 1,099 | 978
Other assets | (2,365) | (136) | (420)
Accounts payable | (714) | (298) | 1,970
Accrued liabilities ($(1,343), $(430) and $(2,549) from related party) | 9,196 | 2,965 | (2,126)
Deferred revenue | 5,502 | 16,837 | 27,654
Lease financing liability | 1,023 | 814 | 627
Other long-term liabilities | 1,619 | 1,897 | 4,225
Net cash provided by (used in) operating activities | (66,513) | 7,108 | (18,571)
Investing activities |  |  |
Purchases of property and equipment | (8,500) | (1,252) | (1,977)
Proceeds from sale of property and equipment | 5 | 0 | 2
Purchases of available-for-sale securities | (169) | (9,041) | (41,736)
Proceeds from sales of available-for-sale securities | 21,109 | 4,298 | 15,342
Proceeds from maturities of available-for-sale securities | 57,421 | 12,617 | 22,501
Net cash provided by (used in) investing activities | 69,866 | 6,622 | (5,868)
Financing activities |  |  |
Repayments of lease liability | (403) | (403) | (403)
Proceeds from follow-on offerings, net of underwriting discounts and commission costs | 471,205 | 0 | 0
Cash paid for payroll taxes on restricted stock unit releases | (8,296) | (2,740) | (2,243)
Proceeds from issuance of common stock | 34,910 | 9,881 | 14,992
Payments of deferred offering costs | (944) | 0 | 0
Net cash provided by financing activities | 496,472 | 6,738 | 12,346
Effect of exchange rate change on cash and cash equivalents | 51 | (10) | (38)
Net increase (decrease) in cash and cash equivalents | 499,876 | 20,458 | (12,131)
Total cash and cash equivalents at beginning of period | 173,782 | 153,324 | 165,455
Total cash and cash equivalents at end of period | 673,658 | 173,782 | 153,324
Supplemental cash flow information: |  |  |
Interest payments | 255 | 295 | 335
Balance in accounts payable and accrued liabilities related to purchases of property and equipment | 3,781 | 356 | 931
Deferred offering costs recorded in accounts payable and accrued liabilities | $ 35 | $ 0 | $ 0

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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3213-108585 + Details
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- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3255-108585 + Details
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- Definition The cash inflow associated with maturities (principal being due), prepayments and calls (requests of early payments) on securities not classified as either held-to-maturity securities or trading securities which are classified as available-for-sale securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3179-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=82896770&loc=d3e26853-111562 + Details
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- Definition The cash inflow associated with the sale of debt and equity securities classified as available-for-sale securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=82896770&loc=d3e26853-111562 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3179-108585 + Details
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- Definition The cash inflow from the sale of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3179-108585 + Details
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- Definition The cash outflow for the obligation for a lease meeting the criteria for capitalization (with maturities exceeding one year or beyond the operating cycle of the entity, if longer). + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3291-108585 + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3602-108585 + Details
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- References No definition available. + Details
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- Definition The net change in the difference between the fair value and the carrying value, or in the comparative fair values, of investments, not including unrealized gains or losses on securities separately or otherwise categorized as trading, available-for-sale, or held-to-maturity, held at each balance sheet date and included in earnings for the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3602-108585 + Details
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