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Balance Sheet Components | 12 Months Ended
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Dec. 31, 2017
Organization Consolidation And Presentation Of Financial Statements [Abstract] |
Balance Sheet Components |
5. | Balance Sheet Components
Cash and Cash Equivalents Cash and cash equivalents consisted of the following (in thousands):
|  | December 31, |
|  | 2017 |  |  | 2016 |
Cash |  | $ | 103,716 |  |  | $ | 79,239 |
Money market funds |  |  | 569,942 |  |  |  | 94,543 |
Total cash and cash equivalents |  | $ | 673,658 |  |  | $ | 173,782 |
Property and Equipment Property and equipment consisted of the following (in thousands):
|  | December 31, |
|  | 2017 |  |  | 2016 |
Laboratory equipment |  | $ | 19,497 |  |  | $ | 18,533 |
Computer equipment |  |  | 6,006 |  |  |  | 5,678 |
Furniture and fixtures |  |  | 5,575 |  |  |  | 5,533 |
Leasehold improvements |  |  | 93,758 |  |  |  | 93,564 |
Building shell (Refer to Note 8) |  |  | 53,879 |  |  |  | 53,879 |
Construction in progress |  |  | 10,402 |  |  |  | 109 |
Total property and equipment |  | $ | 189,117 |  |  | $ | 177,296 |
Less: accumulated depreciation |  |  | (59,641 | ) |  |  | (53,639 | )
Property and equipment, net |  | $ | 129,476 |  |  | $ | 123,657 |
Depreciation expense for the years ended December 31, 2017, 2016 and 2015 was $6.1 million, $6.0 million, and $5.7 million, respectively. Investments All investments are classified as available-for-sale. The amortized cost, gross unrealized holding gains or losses, and fair value of the Company’s available-for-sale investments by major investments type are summarized in the tables below (in thousands):
|  | December 31, 2017 |
|  | Amortized Cost |  |  | Gross Unrealized Holding Gains |  |  | Gross Unrealized Holding Losses |  |  | Fair Value |
Corporate bonds |  | $ | 53,985 |  |  | $ | 4 |  |  | $ | (46 | ) |  | $ | 53,943 |
Bond and mutual funds |  |  | 17,249 |  |  |  | 1,153 |  |  |  | — |  |  |  | 18,402 |
Equity investments |  |  | 126 |  |  |  | 95 |  |  |  | — |  |  |  | 221 |
Total investments |  | $ | 71,360 |  |  | $ | 1,252 |  |  | $ | (46 | ) |  | $ | 72,566 |
|  | December 31, 2016 |
|  | Amortized Cost |  |  | Gross Unrealized Holding Gains |  |  | Gross Unrealized Holding Losses |  |  | Fair Value |
Corporate bonds |  | $ | 126,550 |  |  | $ | 182 |  |  | $ | (49 | ) |  | $ | 126,683 |
Certificate of deposits |  |  | 1,037 |  |  |  | — |  |  |  | — |  |  |  | 1,037 |
Bond and mutual funds |  |  | 22,305 |  |  |  | 157 |  |  |  | — |  |  |  | 22,462 |
Equity investments |  |  | 125 |  |  |  | 100 |  |  |  | — |  |  |  | 225 |
Total investments |  | $ | 150,017 |  |  | $ | 439 |  |  | $ | (49 | ) |  | $ | 150,407 |
The contractual maturities of available-for-sale investments were as follows (in thousands):
|  | December 31, 2017 |
Within one year |  | $ | 53,943 |
After one year through four years |  |  | — |
Total debt investments |  |  | 53,943 |
Bond and mutual funds |  |  | 18,402 |
Equity investments |  |  | 221 |
Total investments |  | $ | 72,566 |
Available-for-sale investments are reported at fair value and as such, their associated unrealized gains and losses are reported as a separate component of stockholders’ equity within accumulated other comprehensive income (loss). Accrued Liabilities Accrued liabilities consisted of the following (in thousands):
|  | December 31, |
|  | 2017 |  |  | 2016 |
Preclinical and clinical trial accruals |  | $ | 32,321 |  |  | $ | 29,550 |
Payroll and related accruals |  |  | 18,810 |  |  |  | 14,232 |
Property taxes and other |  |  | 4,201 |  |  |  | 451 |
Professional services |  |  | 1,991 |  |  |  | 1,252 |
Other |  |  | 6,458 |  |  |  | 5,429 |
Total accrued liabilities |  | $ | 63,781 |  |  | $ | 50,914 |

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- Definition The entire disclosure for supplemental balance sheet disclosures, including descriptions and amounts for assets, liabilities, and equity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -URI http://asc.fasb.org/topic&trid=2122208 + Details
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