XML 82 R29.htm IDEA: XBRL DOCUMENT
v3.8.0.1

Balance Sheet Components (Tables) | 12 Months Ended
--- | ---
Dec. 31, 2017
Organization Consolidation And Presentation Of Financial Statements [Abstract] |
Schedule of Cash and Cash Equivalents | Cash and cash equivalents consisted of the following (in thousands):
|  | December 31, |
|  | 2017 |  |  | 2016 |
Cash |  | $ | 103,716 |  |  | $ | 79,239 |
Money market funds |  |  | 569,942 |  |  |  | 94,543 |
Total cash and cash equivalents |  | $ | 673,658 |  |  | $ | 173,782 |
Schedule of Property and Equipment | Property and equipment consisted of the following (in thousands):
|  | December 31, |
|  | 2017 |  |  | 2016 |
Laboratory equipment |  | $ | 19,497 |  |  | $ | 18,533 |
Computer equipment |  |  | 6,006 |  |  |  | 5,678 |
Furniture and fixtures |  |  | 5,575 |  |  |  | 5,533 |
Leasehold improvements |  |  | 93,758 |  |  |  | 93,564 |
Building shell (Refer to Note 8) |  |  | 53,879 |  |  |  | 53,879 |
Construction in progress |  |  | 10,402 |  |  |  | 109 |
Total property and equipment |  | $ | 189,117 |  |  | $ | 177,296 |
Less: accumulated depreciation |  |  | (59,641 | ) |  |  | (53,639 | )
Property and equipment, net |  | $ | 129,476 |  |  | $ | 123,657 |
Summary of Amortized Cost, Gross Unrealized Holding Gains or Losses, and Fair Value of Available-for-Sale Investments | All investments are classified as available-for-sale. The amortized cost, gross unrealized holding gains or losses, and fair value of the Company’s available-for-sale investments by major investments type are summarized in the tables below (in thousands):
|  | December 31, 2017 |
|  | Amortized Cost |  |  | Gross Unrealized Holding Gains |  |  | Gross Unrealized Holding Losses |  |  | Fair Value |
Corporate bonds |  | $ | 53,985 |  |  | $ | 4 |  |  | $ | (46 | ) |  | $ | 53,943 |
Bond and mutual funds |  |  | 17,249 |  |  |  | 1,153 |  |  |  | — |  |  |  | 18,402 |
Equity investments |  |  | 126 |  |  |  | 95 |  |  |  | — |  |  |  | 221 |
Total investments |  | $ | 71,360 |  |  | $ | 1,252 |  |  | $ | (46 | ) |  | $ | 72,566 |
|  | December 31, 2016 |
|  | Amortized Cost |  |  | Gross Unrealized Holding Gains |  |  | Gross Unrealized Holding Losses |  |  | Fair Value |
Corporate bonds |  | $ | 126,550 |  |  | $ | 182 |  |  | $ | (49 | ) |  | $ | 126,683 |
Certificate of deposits |  |  | 1,037 |  |  |  | — |  |  |  | — |  |  |  | 1,037 |
Bond and mutual funds |  |  | 22,305 |  |  |  | 157 |  |  |  | — |  |  |  | 22,462 |
Equity investments |  |  | 125 |  |  |  | 100 |  |  |  | — |  |  |  | 225 |
Total investments |  | $ | 150,017 |  |  | $ | 439 |  |  | $ | (49 | ) |  | $ | 150,407 |
Summary of Contractual Maturities Available-for-Sale Investments at Fair Value | The contractual maturities of available-for-sale investments were as follows (in thousands):
|  | December 31, 2017 |
Within one year |  | $ | 53,943 |
After one year through four years |  |  | — |
Total debt investments |  |  | 53,943 |
Bond and mutual funds |  |  | 18,402 |
Equity investments |  |  | 221 |
Total investments |  | $ | 72,566 |
Schedule of Accrued Liabilities | Accrued liabilities consisted of the following (in thousands):
|  | December 31, |
|  | 2017 |  |  | 2016 |
Preclinical and clinical trial accruals |  | $ | 32,321 |  |  | $ | 29,550 |
Payroll and related accruals |  |  | 18,810 |  |  |  | 14,232 |
Property taxes and other |  |  | 4,201 |  |  |  | 451 |
Professional services |  |  | 1,991 |  |  |  | 1,252 |
Other |  |  | 6,458 |  |  |  | 5,429 |
Total accrued liabilities |  | $ | 63,781 |  |  | $ | 50,914 |

X
- Definition Tabular disclosure of maturities of an entity's investments as well as any other information pertinent to the investments. + References No definition available. + Details
Name: | us-gaap_InvestmentsClassifiedByContractualMaturityDateTableTextBlock
Namespace Prefix: | us-gaap_
Data Type: | nonnum:textBlockItemType
Balance Type: | na
Period Type: | duration

X
- References No definition available. + Details
Name: | us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract
Namespace Prefix: | us-gaap_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

X
- Definition Tabular disclosure of physical assets used in the normal conduct of business and not intended for resale. Includes, but is not limited to, balances by class of assets, depreciation and depletion expense and method used, including composite depreciation, and accumulated deprecation. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 360 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6391035&loc=d3e2868-110229 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(13)) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
Name: | us-gaap_PropertyPlantAndEquipmentTextBlock
Namespace Prefix: | us-gaap_
Data Type: | nonnum:textBlockItemType
Balance Type: | na
Period Type: | duration

X
- Definition Tabular disclosure of the components of accrued liabilities. + References No definition available. + Details
Name: | us-gaap_ScheduleOfAccruedLiabilitiesTableTextBlock
Namespace Prefix: | us-gaap_
Data Type: | nonnum:textBlockItemType
Balance Type: | na
Period Type: | duration

X
- Definition Tabular disclosure of the reconciliation of available-for-sale securities from cost basis to fair value. + References No definition available. + Details
Name: | us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock
Namespace Prefix: | us-gaap_
Data Type: | nonnum:textBlockItemType
Balance Type: | na
Period Type: | duration

X
- Definition Tabular disclosure of the components of cash and cash equivalents. + References No definition available. + Details
Name: | us-gaap_ScheduleOfCashAndCashEquivalentsTableTextBlock
Namespace Prefix: | us-gaap_
Data Type: | nonnum:textBlockItemType
Balance Type: | na
Period Type: | duration