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Equity and Stock-based Compensation (Tables)
12 Months Ended
Dec. 31, 2017
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]  
Summary of Common Stock Reserved for Future Issuance

Shares of Common Stock outstanding, shares of stock plans outstanding and shares reserved for future issuance related to stock options and RSUs grant and the Company’s Employee Stock Purchase Plan (“ESPP”) purchases are as follows (in thousands):

 

 

 

December 31,

 

 

 

2017

 

 

2016

 

Common stock outstanding

 

 

82,498

 

 

 

63,665

 

Stock options outstanding

 

 

11,550

 

 

 

13,660

 

RSUs outstanding

 

 

1,562

 

 

 

1,211

 

Common stock warrants outstanding

 

 

4

 

 

 

4

 

Shares reserved for future stock options and RSUs grant

 

 

4,190

 

 

 

4,032

 

Shares reserved for future ESPP offering

 

 

2,024

 

 

 

1,638

 

Total shares of common stock reserved

 

 

101,828

 

 

 

84,210

 

 

Summary of Stock Option Transactions

Stock option transactions, including forfeited options granted under the 2014 Plan as well as prior plans, are summarized below:

 

 

 

Shares

(In thousands)

 

 

Weighted

Average

Exercise per

Share

 

 

Weighted

Average

Remaining Contractual

Life

(In Years)

 

 

Aggregate

Intrinsic Value

(In thousands)

 

Outstanding at December 31, 2016

 

 

13,660

 

 

$

11.35

 

 

 

 

 

 

 

 

 

Granted

 

 

1,923

 

 

 

26.95

 

 

 

 

 

 

 

 

 

Exercised

 

 

(3,827

)

 

 

8.10

 

 

 

 

 

 

 

 

 

Expired

 

 

(34

)

 

 

24.58

 

 

 

 

 

 

 

 

 

Forfeited

 

 

(172

)

 

 

22.05

 

 

 

 

 

 

 

 

 

Outstanding at December 31, 2017

 

 

11,550

 

 

 

14.82

 

 

 

5.80

 

 

$

376,670

 

Vested and expected to vest, December 31, 2017

 

 

11,550

 

 

 

14.82

 

 

 

5.80

 

 

 

376,670

 

Exercisable at December 31, 2017

 

 

8,319

 

 

$

10.98

 

 

 

4.71

 

 

$

303,049

 

 

Summary of RSU Activity

The following table summarizes RSU activity:

 

 

 

Shares

(In thousands)

 

 

Fair Value at Grant

 

Unvested at December 31, 2016

 

 

1,211

 

 

$

21.60

 

Granted

 

 

978

 

 

 

26.59

 

Vested

 

 

(563

)

 

 

21.34

 

Forfeited

 

 

(64

)

 

 

23.34

 

Unvested at December 31, 2017

 

 

1,562

 

 

$

24.75

 

 

Schedule of Allocated Stock-Based Compensation Expense

Stock-based compensation expense allocated to research and development and general and administrative expense for the years ended December 31, 2017, 2016, and 2015 was as follows (in thousands):

 

 

 

Years Ended December 31,

 

 

 

2017

 

 

2016

 

 

2015

 

Research and development

 

$

21,807

 

 

$

19,070

 

 

$

16,987

 

General and administrative

 

 

15,732

 

 

 

13,062

 

 

 

10,694

 

Total stock-based compensation expense

 

$

37,539

 

 

$

32,132

 

 

$

27,681

 

 

Schedule of Assumptions used to Estimate Fair Value of Stock Options Granted and Employee Stock Purchase Plans

The assumptions used to estimate the fair value of stock options granted and ESPPs using the Black-Scholes option valuation model were as follows:

 

 

 

Years Ended December 31,

 

 

2017

 

 

 

2016

 

 

 

2015

 

 

Stock Options

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Expected term (in years)

 

 

5.7

 

 

 

 

5.3

 

 

 

 

5.2

 

 

Expected volatility

 

 

71.5

 

%

 

 

69.9

 

%

 

 

69.9

 

%

Risk-free interest rate

 

 

2.2

 

%

 

 

1.4

 

%

 

 

1.7

 

%

Expected dividend yield

 

 

 

 

 

 

 

 

 

 

 

 

Weighted average estimated fair value

 

$

16.96

 

 

 

$

11.49

 

 

 

$

16.12

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ESPPs

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Expected term (in years)

 

0.5 - 2.0

 

 

 

0.5 - 2.0

 

 

 

0.4 - 2.0

 

 

Expected volatility

 

52.8 - 77.2

 

%

 

61.9 - 80.7

 

%

 

58.5 - 69.0

 

%

Risk-free interest rate

 

0.5 - 1.6

 

%

 

0.2 - 1.0

 

%

 

0.1 - 0.6

 

%

Expected dividend yield

 

 

 

 

 

 

 

 

 

 

 

 

Weighted average estimated fair value

 

$

9.41

 

 

 

$

9.94

 

 

 

$

13.03

 

 

 

Schedule of Warrants to Purchase Shares of Common Stock

The following warrants to purchase shares of Common Stock were issued in connection with certain facility and equipment lease financing arrangements and are outstanding at December 31, 2017:

 

Year of Issuance

 

Number of Shares

 

 

Exercise Price per Share

 

 

Reason for Issuance

 

Expiration Date

2000

 

 

4,430

 

 

$

15.00

 

 

Issued in connection with lease agreement

 

Five years after initial public offering or upon merger or sale of the Company’s assets, whichever occurs first

 

 

 

4,430