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Income Taxes (Tables)
12 Months Ended
Dec. 31, 2017
Income Tax Disclosure [Abstract]  
Schedule of Components of Loss Before Income Taxes

The components of loss before income taxes are as follows (in thousands):

 

 

 

Years Ended December 31,

 

 

 

2017

 

 

2016

 

 

2015

 

Domestic

 

$

(101,234

)

 

$

(38,156

)

 

$

(66,411

)

Foreign

 

 

(24,648

)

 

 

(23,595

)

 

 

(19,126

)

Loss before provision for income taxes

 

$

(125,882

)

 

$

(61,751

)

 

$

(85,537

)

 

Schedule of Components of Provision For (Benefit From) Income Taxes

The provision for (benefit from) income taxes consists of the following (in thousands):

 

 

 

Years Ended December 31,

 

 

 

2017

 

 

2016

 

 

2015

 

Current:

 

 

 

 

 

 

 

 

 

 

 

 

Federal

 

$

 

 

$

 

 

$

 

State

 

 

2

 

 

 

2

 

 

 

2

 

Foreign

 

 

319

 

 

 

139

 

 

 

240

 

Total current

 

$

321

 

 

$

141

 

 

$

242

 

Deferred:

 

 

 

 

 

 

 

 

 

 

 

 

Federal

 

$

 

 

$

(212

)

 

$

 

State

 

 

 

 

 

 

 

 

 

Foreign

 

 

 

 

 

 

 

 

 

Total deferred

 

$

 

 

$

(212

)

 

$

 

Total provision for (benefit from) income taxes

 

$

321

 

 

$

(71

)

 

$

242

 

 

Schedule of Reconciliation Between Statutory Federal Income Tax Rate and Effective Tax Rate

 

The following is the reconciliation between the statutory federal income tax rate and the Company’s effective tax rate:

 

 

Years Ended December 31,

 

 

2017

 

 

2016

 

 

2015

 

Tax at statutory federal rate

 

34.0

%

 

 

34.0

%

 

 

34.0

%

State tax

 

%

 

 

%

 

 

%

Stock-based compensation expense

 

18.5

%

 

 

(7.9

)%

 

 

(4.6

)%

Change in deferred tax assets due to rate change

 

43.9

%

 

 

%

 

 

%

Change in valuation allowance due to rate change

 

(43.9

)%

 

 

%

 

 

%

Net operating losses not benefitted

 

(43.8

)%

 

 

(12.9

)%

 

 

(21.7

)%

Foreign net operating losses benefitted

 

(6.7

)%

 

 

(13.0

)%

 

 

(7.6

)%

Orphan drug credit

 

(2.0

)%

 

 

%

 

 

%

Other

 

(0.3

)%

 

 

(0.1

)%

 

 

(0.4

)%

Total

 

(0.3

)%

 

 

0.1

%

 

 

(0.3

)%

 

Schedule of Significant Components of Deferred Tax Assets

Significant components of the Company’s deferred tax assets are as follows (in thousands):

 

 

 

December 31,

 

 

 

2017

 

 

2016

 

Federal and state net operating loss carryforwards

 

$

71,256

 

 

$

42,900

 

Tax credit carryforwards

 

 

39,488

 

 

 

29,846

 

Foreign net operating loss carryforwards

 

 

15,052

 

 

 

11,704

 

Stock-based compensation

 

 

7,835

 

 

 

11,231

 

Lease obligations

 

 

2,737

 

 

 

4,414

 

Reserves and accruals

 

 

4,851

 

 

 

5,465

 

Deferred revenue

 

 

18,103

 

 

 

22,909

 

Other

 

 

420

 

 

 

741

 

Subtotal

 

 

159,742

 

 

 

129,210

 

Less: Valuation allowance

 

 

(159,540

)

 

 

(128,995

)

Net deferred tax assets

 

 

202

 

 

 

215

 

 

 

 

 

 

 

 

 

 

Fixed assets

 

 

(181

)

 

 

(122

)

Other

 

 

(21

)

 

 

(93

)

Net deferred tax liabilities

 

 

(202

)

 

 

(215

)

Total net deferred tax assets

 

$

 

 

$

 

 

Schedule of Reconciliation of the Beginning and Ending Amounts of Unrecognized Income Tax Benefits

A reconciliation of the beginning and ending amounts of unrecognized income tax benefits during the three years ended December 31, 2017 is as follows (in thousands):

 

 

 

Federal and State

 

Balance as of December 31, 2014

 

$

19,122

 

Decrease due to prior positions

 

 

(2,382

)

Increase due to current year position

 

 

7,473

 

Balance as of December 31, 2015

 

 

24,213

 

Decrease due to prior positions

 

 

(7,109

)

Increase due to current year position

 

 

2,550

 

Balance as of December 31, 2016

 

 

19,654

 

Increase due to prior positions

 

 

303

 

Increase due to current year position

 

 

5,448

 

Decrease due to U.S. tax rate change

 

 

(2,044

)

Balance as of December 31, 2017

 

$

23,361