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Consolidated Statements of Operations - USD ($)
shares in Thousands, $ in Thousands
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Revenue:      
License and milestone revenue (includes $15,307, $24,421 and $18,701 from a related party) $ 96,056 $ 137,352 $ 148,093
Collaboration services and other revenue (includes $1,578, $1,357 and $2,895 from a related party) 29,612 42,225 32,735
Total revenue 125,668 179,577 180,828
Operating expenses:      
Research and development 196,517 187,206 214,089
General and administrative 51,760 46,025 44,364
Total operating expenses 248,277 233,231 258,453
Loss from operations (122,609) (53,654) (77,625)
Interest and other, net      
Interest expense (9,706) (10,725) (11,033)
Interest income and other, net 6,433 2,628 3,121
Total interest and other, net (3,273) (8,097) (7,912)
Loss before income taxes (125,882) (61,751) (85,537)
Provision for (benefit from) income taxes 321 (71) 242
Net loss $ (126,203) $ (61,680) $ (85,779)
Net loss per share - basic and diluted $ (1.73) $ (0.98) $ (1.42)
Weighted average number of common shares used to calculate net loss per share - basic and diluted 72,987 62,744 60,337