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Balance Sheet Components - Schedule of Property and Equipment (Detail) - USD ($)
$ in Thousands
Dec. 31, 2017
Dec. 31, 2016
Property Plant And Equipment [Line Items]    
Property and equipment, gross $ 189,117 $ 177,296
Less: accumulated depreciation (59,641) (53,639)
Property and equipment, net 129,476 123,657
Laboratory Equipment [Member]    
Property Plant And Equipment [Line Items]    
Property and equipment, gross 19,497 18,533
Computer Equipment [Member]    
Property Plant And Equipment [Line Items]    
Property and equipment, gross 6,006 5,678
Furniture and Fixtures [Member]    
Property Plant And Equipment [Line Items]    
Property and equipment, gross 5,575 5,533
Leasehold improvements [Member]    
Property Plant And Equipment [Line Items]    
Property and equipment, gross 93,758 93,564
Building shell [Member]    
Property Plant And Equipment [Line Items]    
Property and equipment, gross 53,879 53,879
Construction in progress [Member]    
Property Plant And Equipment [Line Items]    
Property and equipment, gross $ 10,402 $ 109