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Consolidated Statements of Operations (Parenthetical) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
License and milestone revenue from a related party $ 96,056 $ 137,352 $ 148,093
Collaboration services and other revenue from a related party 29,612 42,225 32,735
Astellas Agreement [Member]      
License and milestone revenue from a related party 15,307 24,421 18,701
Collaboration services and other revenue from a related party $ 1,578 $ 1,357 $ 2,895