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Significant Accounting Policies - Schedule of Adoption of New Revenue Standards (Detail) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended |
--- | --- | ---
Mar. 31, 2018 | Mar. 31, 2017 | Dec. 31, 2017
Statement of Operations |  |  |
License revenue | $ 0 | $ 0 |
Development and other revenue | 31,925 | 29,442 |
Total revenue | 31,925 | 29,442 |
Net loss | $ (41,396) | $ (30,610) |
Net loss per share - basic and diluted | $ (0.50) | $ (0.48) |
Balance Sheet |  |  |
Deferred revenue | $ 16,934 |  | $ 16,670
Deferred revenue, net of current | 137,972 |  | 138,241
Accumulated deficit | $ (670,803) |  | (630,657)
As Previously Reported [Member] | ASU 2014-09 [Member] |  |  |
Statement of Operations |  |  |
License revenue |  | $ 19,581 |
Development and other revenue |  | 7,310 |
Total revenue |  | 26,891 |
Net loss |  | $ (33,161) |
Net loss per share - basic and diluted |  | $ (0.52) |
Balance Sheet |  |  |
Deferred revenue |  |  | 7,968
Deferred revenue, net of current |  |  | 112,231
Accumulated deficit |  |  | (595,945)
New Revenue Standards Adjustment [Member] | ASU 2014-09 [Member] |  |  |
Statement of Operations |  |  |
License revenue |  | $ (19,581) |
Development and other revenue |  | 22,132 |
Total revenue |  | 2,551 |
Net loss |  | $ 2,551 |
Net loss per share - basic and diluted |  | $ 0.04 |
Balance Sheet |  |  |
Deferred revenue |  |  | 8,702
Deferred revenue, net of current |  |  | 26,010
Accumulated deficit |  |  | $ (34,712)

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