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Balance Sheet Components (Tables) | 3 Months Ended
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Mar. 31, 2018
Organization Consolidation And Presentation Of Financial Statements [Abstract] |
Schedule of Cash and Cash Equivalents | Cash and cash equivalents consisted of the following (in thousands):
|  | March 31, 2018 |  |  | December 31, 2017 |
Cash |  | $ | 69,559 |  |  | $ | 103,716 |
Money market funds |  |  | 589,448 |  |  |  | 569,942 |
Total cash and cash equivalents |  | $ | 659,007 |  |  | $ | 673,658 |
Summary of Amortized Cost, Gross Unrealized Holding Gains or Losses, and Fair Value of Available-for-Sale Investments | The Company’s investments consist of available-for-sale debt investments and marketable equity investments. The amortized cost, gross unrealized holding gains or losses, and fair value of the Company’s available-for-sale investments by major investments type are summarized in the tables below (in thousands):
|  | March 31, 2018 |
|  | Amortized Cost |  |  | Gross Unrealized Holding Gains |  |  | Gross Unrealized Holding Losses |  |  | Fair Value |
Corporate bonds |  | $ | 36,529 |  |  | $ | — |  |  | $ | (92 | ) |  | $ | 36,437 |
Bond and mutual funds |  |  | 17,293 |  |  |  | 1,338 |  |  |  | — |  |  |  | 18,631 |
Equity investments |  |  | 125 |  |  |  | 74 |  |  |  | — |  |  |  | 199 |
Total investments |  | $ | 53,947 |  |  | $ | 1,412 |  |  | $ | (92 | ) |  | $ | 55,267 |
|  | December 31, 2017 |
|  | Amortized Cost |  |  | Gross Unrealized Holding Gains |  |  | Gross Unrealized Holding Losses |  |  | Fair Value |
Corporate bonds |  | $ | 53,985 |  |  | $ | 4 |  |  | $ | (46 | ) |  | $ | 53,943 |
Bond and mutual funds |  |  | 17,249 |  |  |  | 1,153 |  |  |  | — |  |  |  | 18,402 |
Equity investments |  |  | 126 |  |  |  | 95 |  |  |  | — |  |  |  | 221 |
Total investments |  | $ | 71,360 |  |  | $ | 1,252 |  |  | $ | (46 | ) |  | $ | 72,566 |
Schedule of Accrued Liabilities | Accrued liabilities consisted of the following (in thousands):
|  | March 31, 2018 |  |  | December 31, 2017 |
Preclinical and clinical trial accruals |  | $ | 37,717 |  |  | $ | 32,321 |
Payroll and related accruals |  |  | 11,919 |  |  |  | 18,810 |
Property taxes and other |  |  | 3,150 |  |  |  | 4,201 |
Professional services |  |  | 2,520 |  |  |  | 1,991 |
Other |  |  | 7,553 |  |  |  | 6,458 |
Total accrued liabilities |  | $ | 62,859 |  |  | $ | 63,781 |

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