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Collaboration Agreements - Astellas Agreements - Additional Information (Detail) - Astellas Agreement [Member] - USD ($) | 1 Months Ended | 3 Months Ended | 12 Months Ended | 35 Months Ended | 45 Months Ended
--- | --- | --- | --- | --- | ---
Apr. 30, 2006 | Jun. 30, 2005 | Mar. 31, 2018 | Jun. 30, 2016 | Dec. 31, 2013 | Dec. 31, 2012 | Dec. 31, 2010 | Feb. 28, 2009 | Feb. 28, 2009
Japan [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Upfront, non-contingent and time-based payments received |  |  |  |  |  |  |  |  | $ 40,100,000
Potential milestone payments |  | $ 132,500,000 |  |  |  |  |  |  |
Commercial sales milestone |  | 15,000,000 |  |  |  |  |  |  |
Clinical development milestones |  |  |  |  | $ 12,500,000 |  |  |  |
Milestones revenue |  |  |  | $ 10,000,000 |  |  |  |  |
Japan [Member] | Clinical and Development Milestone [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Potential milestone payments |  | 22,500,000 |  |  |  |  |  |  |
Japan [Member] | Regulatory Milestone [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Potential milestone payments |  | $ 95,000,000 |  |  |  |  |  |  |
Europe [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Upfront, non-contingent and time-based payments received |  |  |  |  |  |  |  | $ 320,000,000 |
Potential milestone payments | $ 425,000 |  |  |  |  |  |  |  |
Clinical development milestones |  |  |  |  |  | $ 50,000,000 | $ 40,000,000 |  |
Percentage of joint development costs committed to fund | 50.00% |  |  |  |  |  |  |  |
Additional consideration based on net sales description |  |  | Low 20% range |  |  |  |  |  |
Europe [Member] | Clinical and Development Milestone [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Potential milestone payments | $ 90,000 |  |  |  |  |  |  |  |
Europe [Member] | Regulatory Milestone [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Potential milestone payments | $ 335,000 |  |  |  |  |  |  |  |

X
- Definition The amount of additional consideration based on net sales of product as defined under a collaboration agreement. + References No definition available. + Details
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X
- Definition Represents the amount of milestone payments related to clinical development under the collaborative agreement. + References No definition available. + Details
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X
- Definition Represents the amount of milestone payments related to commercial sales under the collaborative agreement. + References No definition available. + Details
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- Definition Represents the percentage of costs that will be funded by the other party under a collaborative agreement for development costs. + References No definition available. + Details
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- Definition Represents the total potential amount of milestone payments related to development, regulatory approval and commercial sales under the collaborative agreement. + References No definition available. + Details
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- Definition Represents the amount of fixed and determinable non-contingent upfront payments included under the collaborative agreement as arrangement consideration. + References No definition available. + Details
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- Definition Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. + References No definition available. + Details
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- Definition The amount of consideration recognized during the period for the milestone or milestones. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 605 -SubTopic 28 -Section 50 -Paragraph 2 -Subparagraph (e) -URI http://asc.fasb.org/extlink&oid=68058744&loc=SL6892177-166501 + Details
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- Details
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- Details
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