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Significant Accounting Policies - Schedule of Adoption of New Revenue Standards (Detail) - USD ($)
$ / shares in Units, $ in Thousands
 3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Dec. 31, 2017
Statement of Operations      
License revenue $ 0 $ 0  
Development and other revenue 31,925 29,442  
Total revenue 31,925 29,442  
Net loss $ (41,396) $ (30,610)  
Net loss per share - basic and diluted $ (0.50) $ (0.48)  
Balance Sheet      
Deferred revenue $ 16,934   $ 16,670
Deferred revenue, net of current 137,972   138,241
Accumulated deficit $ (670,803)   (630,657)
As Previously Reported [Member] | ASU 2014-09 [Member]      
Statement of Operations      
License revenue   $ 19,581  
Development and other revenue   7,310  
Total revenue   26,891  
Net loss   $ (33,161)  
Net loss per share - basic and diluted   $ (0.52)  
Balance Sheet      
Deferred revenue     7,968
Deferred revenue, net of current     112,231
Accumulated deficit     (595,945)
New Revenue Standards Adjustment [Member] | ASU 2014-09 [Member]      
Statement of Operations      
License revenue   $ (19,581)  
Development and other revenue   22,132  
Total revenue   2,551  
Net loss   $ 2,551  
Net loss per share - basic and diluted   $ 0.04  
Balance Sheet      
Deferred revenue     8,702
Deferred revenue, net of current     26,010
Accumulated deficit     $ (34,712)