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Collaboration Agreements - Astellas Agreements - Additional Information (Detail) - Astellas Agreement [Member] - USD ($)
1 Months Ended 3 Months Ended 12 Months Ended 35 Months Ended 45 Months Ended
Apr. 30, 2006
Jun. 30, 2005
Mar. 31, 2018
Jun. 30, 2016
Dec. 31, 2013
Dec. 31, 2012
Dec. 31, 2010
Feb. 28, 2009
Feb. 28, 2009
Japan [Member]                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Upfront, non-contingent and time-based payments received                 $ 40,100,000
Potential milestone payments   $ 132,500,000              
Commercial sales milestone   15,000,000              
Clinical development milestones         $ 12,500,000        
Milestones revenue       $ 10,000,000          
Japan [Member] | Clinical and Development Milestone [Member]                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Potential milestone payments   22,500,000              
Japan [Member] | Regulatory Milestone [Member]                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Potential milestone payments   $ 95,000,000              
Europe [Member]                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Upfront, non-contingent and time-based payments received               $ 320,000,000  
Potential milestone payments $ 425,000                
Clinical development milestones           $ 50,000,000 $ 40,000,000    
Percentage of joint development costs committed to fund 50.00%                
Additional consideration based on net sales description     Low 20% range            
Europe [Member] | Clinical and Development Milestone [Member]                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Potential milestone payments $ 90,000                
Europe [Member] | Regulatory Milestone [Member]                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Potential milestone payments $ 335,000