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Collaboration Agreements - Accounting for the Astellas Agreements - Additional Information 2 (Detail) - Astellas Agreement [Member]
3 Months Ended
Mar. 31, 2018
USD ($)
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]  
Co-development services, currently estimated continuation year 2019
Manufacturing Commercial Supplies of Products [Member]  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]  
Manufacturing commercial supplies of products, revenue recognized $ 0
Minimum [Member]  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]  
Discount rate applied 17.50%
Maximum [Member]  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]  
Discount rate applied 20.00%
Japan [Member]  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]  
Non-contingent upfront payments received $ 40,100,000
Variable consideration related to payments for milestones considered probable of being achieved 22,500,000
Variable consideration related to co-development billings 12,300,000
Provision for co-development services 0
Europe [Member]  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]  
Non-contingent upfront payments received 320,000,000
Variable consideration related to payments for milestones considered probable of being achieved 90,000,000
Variable consideration related to co-development billings $ 183,000,000