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Collaboration Agreements - Summary of Revenue Recognized Under the Collaboration Agreements - Additional Information 4 (Detail)
$ in Millions
3 Months Ended
Mar. 31, 2018
USD ($)
Japan [Member]  
Revenue Recognition, Multiple-deliverable Arrangements [Line Items]  
Remainder of transaction price, variable consideration from estimated future co-development billing $ 2.8
Europe [Member]  
Revenue Recognition, Multiple-deliverable Arrangements [Line Items]  
Remainder of transaction price, variable consideration from estimated future co-development billing 27.4
U.S./RoW and China [Member]  
Revenue Recognition, Multiple-deliverable Arrangements [Line Items]  
Remainder of transaction price, variable consideration from estimated future co-development billing $ 284.1