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Stock-Based Compensation - Schedule of Assumptions used to Estimate Fair Value of Stock Options Granted and Purchases under 2014 Employee Share Purchase Plan (Detail) - $ / shares
3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Employee stock options [Member]    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]    
Expected term (in years) 5 years 4 months 24 days 5 years 9 months 18 days
Expected volatility 67.90% 71.70%
Risk-free interest rate 2.70% 2.30%
Expected dividend yield 0.00% 0.00%
Weighted average estimated fair value $ 32.18 $ 16.16
2014 Employee Share Purchase Plan [Member]    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]    
Expected volatility, minimum 54.90% 63.70%
Expected volatility, maximum 75.30% 77.20%
Risk-free interest rate, minimum 0.80% 0.50%
Risk-free interest rate, maximum 1.60% 1.00%
Expected dividend yield 0.00% 0.00%
Weighted average estimated fair value $ 10.93 $ 8.86
2014 Employee Share Purchase Plan [Member] | Minimum [Member]    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]    
Expected term (in years) 6 months 6 months
2014 Employee Share Purchase Plan [Member] | Maximum [Member]    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]    
Expected term (in years) 2 years 2 years