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v3.10.0.1

Condensed Consolidated Statements of Operations (Unaudited) - USD ($) shares in Thousands, $ in Thousands | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2018 | Jun. 30, 2017 | Jun. 30, 2018 | Jun. 30, 2017
Revenue: |  |  |  |
Total revenue | $ 43,952 | $ 30,268 | $ 75,876 | $ 59,710
Operating expenses: |  |  |  |
Research and development | 52,138 | 46,981 | 109,112 | 93,713
General and administrative | 15,055 | 13,425 | 30,605 | 24,955
Total operating expenses | 67,193 | 60,406 | 139,717 | 118,668
Loss from operations | (23,241) | (30,138) | (63,841) | (58,958)
Interest and other, net |  |  |  |
Interest expense | (2,750) | (2,757) | (5,519) | (5,132)
Interest income and other, net | 2,646 | 1,031 | 4,717 | 1,677
Total interest and other, net | (104) | (1,726) | (802) | (3,455)
Loss before income taxes | (23,345) | (31,864) | (64,643) | (62,413)
Provision for income taxes | 75 | 48 | 174 | 109
Net loss | $ (23,420) | $ (31,912) | $ (64,817) | $ (62,522)
Net loss per share - basic and diluted | $ (0.28) | $ (0.46) | $ (0.78) | $ (0.94)
Weighted average number of common shares used to calculate net loss per share - basic and diluted | 83,750 | 69,638 | 83,309 | 66,853
License Revenue [Member] |  |  |  |
Revenue: |  |  |  |
Total revenue | $ 14,323 | $ 0 | $ 14,323 | $ 0
Development and Other Revenue [Member] |  |  |  |
Revenue: |  |  |  |
Total revenue | $ 29,629 | $ 30,268 | $ 61,553 | $ 59,710

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