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Significant Accounting Policies - Schedule of Adoption of New Revenue Standards (Detail) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | 6 Months Ended |
--- | --- | --- | ---
Jun. 30, 2018 | Jun. 30, 2017 | Jun. 30, 2018 | Jun. 30, 2017 | Dec. 31, 2017
Statement of Operations |  |  |  |  |
Total revenue | $ 43,952 | $ 30,268 | $ 75,876 | $ 59,710 |
Net loss | $ (23,420) | $ (31,912) | $ (64,817) | $ (62,522) |
Net loss per share - basic and diluted | $ (0.28) | $ (0.46) | $ (0.78) | $ (0.94) |
Balance Sheet |  |  |  |  |
Deferred revenue | $ 37,845 |  | $ 37,845 |  | $ 16,670
Deferred revenue, net of current | 137,436 |  | 137,436 |  | 138,241
Accumulated deficit | (694,224) |  | (694,224) |  | (630,657)
License Revenue [Member] |  |  |  |  |
Statement of Operations |  |  |  |  |
Total revenue | 14,323 | $ 0 | 14,323 | $ 0 |
Development and Other Revenue [Member] |  |  |  |  |
Statement of Operations |  |  |  |  |
Total revenue | $ 29,629 | 30,268 | $ 61,553 | 59,710 |
As Previously Reported [Member] | ASU 2014-09 [Member] |  |  |  |  |
Statement of Operations |  |  |  |  |
Total revenue |  | 28,997 |  | 55,888 |
Net loss |  | $ (33,183) |  | $ (66,344) |
Net loss per share - basic and diluted |  | $ (0.48) |  | $ (0.99) |
Balance Sheet |  |  |  |  |
Deferred revenue |  |  |  |  | 7,968
Deferred revenue, net of current |  |  |  |  | 112,231
Accumulated deficit |  |  |  |  | (595,945)
As Previously Reported [Member] | License Revenue [Member] | ASU 2014-09 [Member] |  |  |  |  |
Statement of Operations |  |  |  |  |
Total revenue |  | $ 21,352 |  | $ 40,933 |
As Previously Reported [Member] | Development and Other Revenue [Member] | ASU 2014-09 [Member] |  |  |  |  |
Statement of Operations |  |  |  |  |
Total revenue |  | 7,645 |  | 14,955 |
New Revenue Standards Adjustment [Member] | ASU 2014-09 [Member] |  |  |  |  |
Statement of Operations |  |  |  |  |
Total revenue |  | 1,271 |  | 3,822 |
Net loss |  | $ 1,271 |  | $ 3,822 |
Net loss per share - basic and diluted |  | $ 0.02 |  | $ 0.05 |
Balance Sheet |  |  |  |  |
Deferred revenue |  |  |  |  | 8,702
Deferred revenue, net of current |  |  |  |  | 26,010
Accumulated deficit |  |  |  |  | $ (34,712)
New Revenue Standards Adjustment [Member] | License Revenue [Member] | ASU 2014-09 [Member] |  |  |  |  |
Statement of Operations |  |  |  |  |
Total revenue |  | $ (21,352) |  | $ (40,933) |
New Revenue Standards Adjustment [Member] | Development and Other Revenue [Member] | ASU 2014-09 [Member] |  |  |  |  |
Statement of Operations |  |  |  |  |
Total revenue |  | $ 22,623 |  | $ 44,755 |

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