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Collaboration Agreements - Summary of Revenue Recognized under Agreement (Detail) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2018 | Jun. 30, 2017 | Jun. 30, 2018 | Jun. 30, 2017
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |  |
Total revenue | $ 43,952 | $ 30,268 | $ 75,876 | $ 59,710
License Revenue [Member] |  |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |  |
Total revenue | 14,323 | 0 | 14,323 | 0
Development and Other Revenue [Member] |  |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |  |
Total revenue | 29,629 | 30,268 | 61,553 | 59,710
Astellas Agreement [Member] | License Revenue [Member] | Japan [Member] |  |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |  |
Total revenue | 14,323 | 0 | 14,323 | 0
Astellas Agreement [Member] | License Revenue [Member] | Europe [Member] |  |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |  |
Total revenue | 0 | 0 | 0 | 0
Astellas Agreement [Member] | Development and Other Revenue [Member] | Japan [Member] |  |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |  |
Total revenue | 1,142 | 317 | 1,591 | 613
Astellas Agreement [Member] | Development and Other Revenue [Member] | Europe [Member] |  |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |  |
Total revenue | 5,003 | 4,781 | 9,726 | 9,171
AstraZeneca Agreements [Member] | China [Member] |  |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |  |
Total revenue | 0 | 0 | 0 | 0
AstraZeneca Agreements [Member] | License Revenue [Member] | U.S./RoW [Member] |  |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |  |
Total revenue | 0 | 0 | 0 | 0
AstraZeneca Agreements [Member] | Development and Other Revenue [Member] | U.S./RoW [Member] |  |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |  |
Total revenue | $ 23,479 | $ 25,167 | $ 50,202 | $ 49,923

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- Definition Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 32 -Paragraph 2A -URI http://asc.fasb.org/extlink&oid=82859839&loc=SL82860478-203043 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 4 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=82913847&loc=SL49130543-203045 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=82913847&loc=SL49130539-203045 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 5 -URI http://asc.fasb.org/extlink&oid=82913847&loc=SL49130545-203045 + Details
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