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Collaboration Agreements - Accounting for the Astellas Agreements - Additional Information 2 (Detail) - Astellas Agreement [Member] | 6 Months Ended
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Jun. 30, 2018 USD ($)
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |
Co-development services, currently estimated continuation year | 2019
Manufacturing Commercial Supplies of Products [Member] |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |
Manufacturing commercial supplies of products, revenue recognized | $ 0
Minimum [Member] |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |
Discount rate applied | 17.50%
Maximum [Member] |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |
Discount rate applied | 20.00%
Japan [Member] |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |
Non-contingent upfront payments received | $ 40,100,000
Variable consideration related to payments for milestones considered probable of being achieved | 37,500,000
Variable consideration related to co-development billings | 12,700,000
Provision for co-development services | 0
Europe [Member] |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |
Non-contingent upfront payments received | 320,000,000
Variable consideration related to payments for milestones considered probable of being achieved | 90,000,000
Variable consideration related to co-development billings | $ 183,800,000

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- Definition Represents the amount of non-contingent upfront payments included under the collaborative agreement as arrangement consideration. + References No definition available. + Details
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- Definition Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. + References No definition available. + Details
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- Definition Interest rate used to find the present value of an amount to be paid or received in the future as an input to measure fair value. For example, but not limited to, weighted average cost of capital (WACC), cost of capital, cost of equity and cost of debt. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (bbb) -URI http://asc.fasb.org/extlink&oid=66048111&loc=d3e19207-110258 + Details
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- Definition Amount of revenue from the sale of manufactured products, classified as other. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.1(a)) -URI http://asc.fasb.org/extlink&oid=63488584&loc=d3e20235-122688 + Details
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