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Significant Accounting Policies - Schedule of Adoption of New Revenue Standards (Detail) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017	Dec. 31, 2017
Statement of Operations
Total revenue	$ 43,952	$ 30,268	$ 75,876	$ 59,710
Net loss	$ (23,420)	$ (31,912)	$ (64,817)	$ (62,522)
Net loss per share - basic and diluted	$ (0.28)	$ (0.46)	$ (0.78)	$ (0.94)
Balance Sheet
Deferred revenue	$ 37,845		$ 37,845		$ 16,670
Deferred revenue, net of current	137,436		137,436		138,241
Accumulated deficit	(694,224)		(694,224)		(630,657)
License Revenue [Member]
Statement of Operations
Total revenue	14,323	$ 0	14,323	$ 0
Development and Other Revenue [Member]
Statement of Operations
Total revenue	$ 29,629	30,268	$ 61,553	59,710
As Previously Reported [Member] | ASU 2014-09 [Member]
Statement of Operations
Total revenue		28,997		55,888
Net loss		$ (33,183)		$ (66,344)
Net loss per share - basic and diluted		$ (0.48)		$ (0.99)
Balance Sheet
Deferred revenue					7,968
Deferred revenue, net of current					112,231
Accumulated deficit					(595,945)
As Previously Reported [Member] | License Revenue [Member] | ASU 2014-09 [Member]
Statement of Operations
Total revenue		$ 21,352		$ 40,933
As Previously Reported [Member] | Development and Other Revenue [Member] | ASU 2014-09 [Member]
Statement of Operations
Total revenue		7,645		14,955
New Revenue Standards Adjustment [Member] | ASU 2014-09 [Member]
Statement of Operations
Total revenue		1,271		3,822
Net loss		$ 1,271		$ 3,822
Net loss per share - basic and diluted		$ 0.02		$ 0.05
Balance Sheet
Deferred revenue					8,702
Deferred revenue, net of current					26,010
Accumulated deficit					$ (34,712)
New Revenue Standards Adjustment [Member] | License Revenue [Member] | ASU 2014-09 [Member]
Statement of Operations
Total revenue		$ (21,352)		$ (40,933)
New Revenue Standards Adjustment [Member] | Development and Other Revenue [Member] | ASU 2014-09 [Member]
Statement of Operations
Total revenue		$ 22,623		$ 44,755

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