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Stock-Based Compensation - Schedule of Assumptions used to Estimate Fair Value of Stock Options Granted and Purchases under 2014 Employee Share Purchase Plan (Detail) - $ / shares
3 Months Ended 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Jun. 30, 2018
Jun. 30, 2017
Employee stock options [Member]        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Expected term (in years) 5 years 4 months 24 days 5 years 4 months 24 days 5 years 4 months 24 days 5 years 8 months 12 days
Expected volatility 67.50% 71.00% 67.80% 71.60%
Risk-free interest rate 2.80% 1.90% 2.70% 2.30%
Expected dividend yield 0.00% 0.00% 0.00% 0.00%
Weighted average estimated fair value $ 31.35 $ 17.06 $ 32.12 $ 16.26
2014 Employee Share Purchase Plan [Member]        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Expected volatility, minimum 47.30% 52.80% 47.30% 52.80%
Expected volatility, maximum 75.30% 77.20% 75.30% 77.20%
Risk-free interest rate, minimum 0.80% 0.50% 0.80% 0.50%
Risk-free interest rate, maximum 2.60% 1.30% 2.60% 1.30%
Expected dividend yield 0.00% 0.00% 0.00% 0.00%
Weighted average estimated fair value $ 15.25 $ 9.10 $ 13.67 $ 8.98
2014 Employee Share Purchase Plan [Member] | Minimum [Member]        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Expected term (in years) 6 months 6 months 6 months 6 months
2014 Employee Share Purchase Plan [Member] | Maximum [Member]        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Expected term (in years) 2 years 2 years 2 years 2 years