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Condensed Consolidated Statements of Operations (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Revenue:
Total revenue	$ 43,952	$ 30,268	$ 75,876	$ 59,710
Operating expenses:
Research and development	52,138	46,981	109,112	93,713
General and administrative	15,055	13,425	30,605	24,955
Total operating expenses	67,193	60,406	139,717	118,668
Loss from operations	(23,241)	(30,138)	(63,841)	(58,958)
Interest and other, net
Interest expense	(2,750)	(2,757)	(5,519)	(5,132)
Interest income and other, net	2,646	1,031	4,717	1,677
Total interest and other, net	(104)	(1,726)	(802)	(3,455)
Loss before income taxes	(23,345)	(31,864)	(64,643)	(62,413)
Provision for income taxes	75	48	174	109
Net loss	$ (23,420)	$ (31,912)	$ (64,817)	$ (62,522)
Net loss per share - basic and diluted	$ (0.28)	$ (0.46)	$ (0.78)	$ (0.94)
Weighted average number of common shares used to calculate net loss per share - basic and diluted	83,750	69,638	83,309	66,853
License Revenue [Member]
Revenue:
Total revenue	$ 14,323	$ 0	$ 14,323	$ 0
Development and Other Revenue [Member]
Revenue:
Total revenue	$ 29,629	$ 30,268	$ 61,553	$ 59,710

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