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Related Party Transactions - Additional Information (Detail) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017	Dec. 31, 2017
Related Party Transaction [Line Items]
Accounts receivable from related party	$ 25,886		$ 25,886		$ 4,004
Accrued liabilities to related party	327		327		272
Prepaid expenses and other current assets from related party	15,000		15,000		0
Astellas Agreement [Member] | Japan [Member]
Related Party Transaction [Line Items]
Prepaid expenses and other current assets from related party	15,000		15,000
Astellas [Member] | Collaborative Arrangement [Member]
Related Party Transaction [Line Items]
Revenue related to collaboration agreements	20,500	$ 5,100	25,600	$ 9,800
Expense related to collaboration agreements	200	$ 300	700	$ 500
Accounts receivable from related party	25,900		25,900		4,000
Accrued liabilities to related party	300		300		$ 300
Astellas [Member] | Astellas Agreement [Member] | API Shipment [Member]
Related Party Transaction [Line Items]
Accrued liabilities to related party	20,900		20,900
Unbilled Revenues [Member] | Astellas [Member] | Regulatory Milestone [Member]
Related Party Transaction [Line Items]
Revenue related to collaboration agreements	$ 14,900		$ 15,000

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- Definition

Amount of receivables arising from transactions with related parties due within one year or the normal operating cycle, if longer.

+ References

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-Publisher FASB
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The aggregate amount of receivables to be collected from related parties where one party can exercise control or significant influence over another party; including affiliates, owners or officers and their immediate families, pension trusts, and so forth, at the financial statement date. which are usually due within one year (or one business cycle).

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Carrying amount as of the balance sheet date of obligations due all related parties. For classified balance sheets, represents the current portion of such liabilities (due within one year or within the normal operating cycle if longer).

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Expenses recognized resulting from transactions (excluding transactions that are eliminated in consolidated or combined financial statements) with related party.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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