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Related Party Transactions - Additional Information (Detail) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended |
--- | --- | --- | ---
Sep. 30, 2018 | Sep. 30, 2017 | Sep. 30, 2018 | Sep. 30, 2017 | Dec. 31, 2017
Related Party Transaction [Line Items] |  |  |  |  |
Accounts receivable from related party | $ 19,434 |  | $ 19,434 |  | $ 4,004
Accrued liabilities to related party | 353 |  | 353 |  | 272
Astellas [Member] | Collaborative Arrangement [Member] |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |
Revenue related to collaboration agreements | 5,100 | $ 5,300 | 30,800 | $ 15,100 |
Expense related to collaboration agreements | 400 | $ 200 | 1,100 | $ 800 |
Accounts receivable from related party | 19,400 |  | 19,400 |  | 4,000
Accrued liabilities to related party | 400 |  | 400 |  | $ 300
Astellas [Member] | Astellas Agreement [Member] | API Shipment [Member] |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |
Accrued liabilities to related party | 20,900 |  | 20,900 |  |
Unbilled Revenues [Member] | Astellas [Member] | Regulatory Milestone [Member] |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |
Revenue related to collaboration agreements | $ 14,900 |  | $ 15,000 |  |

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