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Significant Accounting Policies - Schedule of Adoption of New Revenue Standards (Detail) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | 9 Months Ended |
--- | --- | --- | ---
Sep. 30, 2018 | Sep. 30, 2017 | Sep. 30, 2018 | Sep. 30, 2017 | Dec. 31, 2017
Statement of Operations |  |  |  |  |
Total revenue | $ 29,027 | $ 40,550 | $ 104,903 | $ 100,260 |
Net loss | $ (42,556) | $ (24,459) | $ (107,373) | $ (86,981) |
Net loss per share - basic and diluted | $ (0.50) | $ (0.32) | $ (1.28) | $ (1.24) |
Balance Sheet |  |  |  |  |
Deferred revenue | $ 37,697 |  | $ 37,697 |  | $ 16,670
Deferred revenue, net of current | 136,874 |  | 136,874 |  | 138,241
Accumulated deficit | (736,780) |  | (736,780) |  | (630,657)
License Revenue [Member] |  |  |  |  |
Statement of Operations |  |  |  |  |
Total revenue | 0 | $ 9,933 | 14,323 | $ 9,933 |
Development and Other Revenue [Member] |  |  |  |  |
Statement of Operations |  |  |  |  |
Total revenue | $ 29,027 | 30,617 | $ 90,580 | 90,327 |
As Previously Reported [Member] | ASU 2014-09 [Member] |  |  |  |  |
Statement of Operations |  |  |  |  |
Total revenue |  | 27,272 |  | 83,160 |
Net loss |  | $ (37,737) |  | $ (104,081) |
Net loss per share - basic and diluted |  | $ (0.50) |  | $ (1.49) |
Balance Sheet |  |  |  |  |
Deferred revenue |  |  |  |  | 7,968
Deferred revenue, net of current |  |  |  |  | 112,231
Accumulated deficit |  |  |  |  | (595,945)
As Previously Reported [Member] | License Revenue [Member] | ASU 2014-09 [Member] |  |  |  |  |
Statement of Operations |  |  |  |  |
Total revenue |  | $ 19,997 |  | $ 60,930 |
As Previously Reported [Member] | Development and Other Revenue [Member] | ASU 2014-09 [Member] |  |  |  |  |
Statement of Operations |  |  |  |  |
Total revenue |  | 7,275 |  | 22,230 |
New Revenue Standards Adjustment [Member] | ASU 2014-09 [Member] |  |  |  |  |
Statement of Operations |  |  |  |  |
Total revenue |  | 13,278 |  | 17,100 |
Net loss |  | $ 13,278 |  | $ 17,100 |
Net loss per share - basic and diluted |  | $ 0.18 |  | $ 0.25 |
Balance Sheet |  |  |  |  |
Deferred revenue |  |  |  |  | 8,702
Deferred revenue, net of current |  |  |  |  | 26,010
Accumulated deficit |  |  |  |  | $ (34,712)
New Revenue Standards Adjustment [Member] | License Revenue [Member] | ASU 2014-09 [Member] |  |  |  |  |
Statement of Operations |  |  |  |  |
Total revenue |  | $ (10,064) |  | $ (50,997) |
New Revenue Standards Adjustment [Member] | Development and Other Revenue [Member] | ASU 2014-09 [Member] |  |  |  |  |
Statement of Operations |  |  |  |  |
Total revenue |  | $ 23,342 |  | $ 68,097 |

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