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Collaboration Agreements - Astellas Agreements - Additional Information (Detail) - USD ($) $ in Thousands | 1 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended | 35 Months Ended | 45 Months Ended |
--- | --- | --- | --- | --- | --- | --- | ---
Jul. 31, 2016 | Apr. 30, 2006 | Jun. 30, 2005 | Jun. 30, 2018 | Sep. 30, 2018 | Dec. 31, 2012 | Dec. 31, 2010 | Feb. 28, 2009 | Feb. 28, 2009 | Dec. 31, 2017
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |
Deferred revenue |  |  |  |  | $ 37,697 |  |  |  |  | $ 16,670
Astellas Agreement [Member] | Japan [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |
Upfront, non-contingent and time-based payments received |  |  |  |  |  |  |  |  | $ 40,100 |
Potential milestone payments |  |  | $ 132,500 |  |  |  |  |  |  |
Commercial sales milestone |  |  | 15,000 |  |  |  |  |  |  |
Milestones revenue | $ 22,500 |  |  |  |  |  |  |  |  |
Consideration associated with milestone included in transaction price |  |  |  | $ 15,000 |  |  |  |  |  |
Changes in revenue due to prior period adjustment |  |  |  | $ 14,900 |  |  |  |  |  |
Deferred revenue |  |  |  |  | 20,900 |  |  |  |  |
Astellas Agreement [Member] | Japan [Member] | Clinical and Development Milestone [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |
Potential milestone payments |  |  | 22,500 |  |  |  |  |  |  |
Astellas Agreement [Member] | Japan [Member] | Regulatory Milestone [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |
Potential milestone payments |  |  | $ 95,000 |  |  |  |  |  |  |
Astellas Agreement [Member] | Europe [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |
Upfront, non-contingent and time-based payments received |  |  |  |  |  |  |  | $ 320,000 |  |
Potential milestone payments |  | $ 425,000 |  |  |  |  |  |  |  |
Changes in revenue due to prior period adjustment |  |  |  |  | $ (100) |  |  |  |  |
Clinical development milestones |  |  |  |  |  | $ 50,000 | $ 40,000 |  |  |
Percentage of joint development costs committed to fund |  | 50.00% |  |  |  |  |  |  |  |
Additional consideration based on net sales description |  |  |  |  | Low 20% range |  |  |  |  |
Astellas Agreement [Member] | Europe [Member] | Clinical and Development Milestone [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |
Potential milestone payments |  | $ 90,000 |  |  |  |  |  |  |  |
Astellas Agreement [Member] | Europe [Member] | Regulatory Milestone [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |
Potential milestone payments |  | $ 335,000 |  |  |  |  |  |  |  |

X
- Definition The amount of additional consideration based on net sales of product as defined under a collaboration agreement. + References No definition available. + Details
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- Definition Represents the amount of milestone payments related to clinical development under the collaborative agreement. + References No definition available. + Details
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- Definition Represents the percentage of costs that will be funded by the other party under a collaborative agreement for development costs. + References No definition available. + Details
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