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Significant Accounting Policies - Schedule of Adoption of New Revenue Standards (Detail) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2018	Sep. 30, 2017	Sep. 30, 2018	Sep. 30, 2017	Dec. 31, 2017
Statement of Operations
Total revenue	$ 29,027	$ 40,550	$ 104,903	$ 100,260
Net loss	$ (42,556)	$ (24,459)	$ (107,373)	$ (86,981)
Net loss per share - basic and diluted	$ (0.50)	$ (0.32)	$ (1.28)	$ (1.24)
Balance Sheet
Deferred revenue	$ 37,697		$ 37,697		$ 16,670
Deferred revenue, net of current	136,874		136,874		138,241
Accumulated deficit	(736,780)		(736,780)		(630,657)
License Revenue [Member]
Statement of Operations
Total revenue	0	$ 9,933	14,323	$ 9,933
Development and Other Revenue [Member]
Statement of Operations
Total revenue	$ 29,027	30,617	$ 90,580	90,327
As Previously Reported [Member] | ASU 2014-09 [Member]
Statement of Operations
Total revenue		27,272		83,160
Net loss		$ (37,737)		$ (104,081)
Net loss per share - basic and diluted		$ (0.50)		$ (1.49)
Balance Sheet
Deferred revenue					7,968
Deferred revenue, net of current					112,231
Accumulated deficit					(595,945)
As Previously Reported [Member] | License Revenue [Member] | ASU 2014-09 [Member]
Statement of Operations
Total revenue		$ 19,997		$ 60,930
As Previously Reported [Member] | Development and Other Revenue [Member] | ASU 2014-09 [Member]
Statement of Operations
Total revenue		7,275		22,230
New Revenue Standards Adjustment [Member] | ASU 2014-09 [Member]
Statement of Operations
Total revenue		13,278		17,100
Net loss		$ 13,278		$ 17,100
Net loss per share - basic and diluted		$ 0.18		$ 0.25
Balance Sheet
Deferred revenue					8,702
Deferred revenue, net of current					26,010
Accumulated deficit					$ (34,712)
New Revenue Standards Adjustment [Member] | License Revenue [Member] | ASU 2014-09 [Member]
Statement of Operations
Total revenue		$ (10,064)		$ (50,997)
New Revenue Standards Adjustment [Member] | Development and Other Revenue [Member] | ASU 2014-09 [Member]
Statement of Operations
Total revenue		$ 23,342		$ 68,097

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