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Collaboration Agreements - Summary of Revenue Recognized under Agreement (Detail) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2018	Sep. 30, 2017	Sep. 30, 2018	Sep. 30, 2017
Revenue Recognition, Multiple-deliverable Arrangements [Line Items]
Total revenue	$ 29,027	$ 40,550	$ 104,903	$ 100,260
License Revenue [Member]
Revenue Recognition, Multiple-deliverable Arrangements [Line Items]
Total revenue	0	9,933	14,323	9,933
Development and Other Revenue [Member]
Revenue Recognition, Multiple-deliverable Arrangements [Line Items]
Total revenue	29,027	30,617	90,580	90,327
Astellas Agreement [Member] | License Revenue [Member] | Japan [Member]
Revenue Recognition, Multiple-deliverable Arrangements [Line Items]
Total revenue	0	0	14,323	0
Astellas Agreement [Member] | License Revenue [Member] | Europe [Member]
Revenue Recognition, Multiple-deliverable Arrangements [Line Items]
Total revenue	0	0	0	0
Astellas Agreement [Member] | Development and Other Revenue [Member] | Japan [Member]
Revenue Recognition, Multiple-deliverable Arrangements [Line Items]
Total revenue	474	517	2,065	1,130
Astellas Agreement [Member] | Development and Other Revenue [Member] | Europe [Member]
Revenue Recognition, Multiple-deliverable Arrangements [Line Items]
Total revenue	4,658	4,805	14,384	13,976
AstraZeneca Agreements [Member] | China [Member]
Revenue Recognition, Multiple-deliverable Arrangements [Line Items]
Total revenue	0	0	0	0
AstraZeneca Agreements [Member] | License Revenue [Member] | U.S./RoW [Member]
Revenue Recognition, Multiple-deliverable Arrangements [Line Items]
Total revenue	0	9,933	0	9,933
AstraZeneca Agreements [Member] | Development and Other Revenue [Member] | U.S./RoW [Member]
Revenue Recognition, Multiple-deliverable Arrangements [Line Items]
Total revenue	$ 23,895	$ 25,295	$ 74,096	$ 75,218

X

- Definition

Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 4
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=109196051&loc=SL49130543-203045

Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=109196051&loc=SL49130539-203045

Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 5
-URI http://asc.fasb.org/extlink&oid=109196051&loc=SL49130545-203045

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+ References

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