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Condensed Consolidated Statements of Operations (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2018	Sep. 30, 2017	Sep. 30, 2018	Sep. 30, 2017
Revenue:
Total revenue	$ 29,027	$ 40,550	$ 104,903	$ 100,260
Operating expenses:
Research and development	56,443	50,336	165,555	144,049
General and administrative	15,356	12,953	45,961	37,908
Total operating expenses	71,799	63,289	211,516	181,957
Loss from operations	(42,772)	(22,739)	(106,613)	(81,697)
Interest and other, net
Interest expense	(2,739)	(2,769)	(8,257)	(7,901)
Interest income and other, net	3,079	1,106	7,796	2,783
Total interest and other, net	340	(1,663)	(461)	(5,118)
Loss before income taxes	(42,432)	(24,402)	(107,074)	(86,815)
Provision for income taxes	124	57	299	166
Net loss	$ (42,556)	$ (24,459)	$ (107,373)	$ (86,981)
Net loss per share - basic and diluted	$ (0.50)	$ (0.32)	$ (1.28)	$ (1.24)
Weighted average number of common shares used to calculate net loss per share - basic and diluted	84,508	75,891	83,713	69,899
License Revenue [Member]
Revenue:
Total revenue	$ 0	$ 9,933	$ 14,323	$ 9,933
Development and Other Revenue [Member]
Revenue:
Total revenue	$ 29,027	$ 30,617	$ 90,580	$ 90,327

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