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Collaboration Agreements - Summary of Revenue Recognized under Agreement (Detail) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |
Total revenue | $ 212,958 | $ 130,996 | $ 183,189
License Revenue [Member] |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |
Total revenue | 22,269 | 9,933 | 50,607
Development Revenue [Member] |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |
Total revenue | 125,913 | 121,063 | 132,582
Astellas Agreement [Member] | License Revenue [Member] | Japan [Member] |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |
Total revenue | 14,323 | 0 | 9,548
Astellas Agreement [Member] | License Revenue [Member] | Europe [Member] |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |
Total revenue | 0 | 0 | 0
Astellas Agreement [Member] | Development Revenue [Member] | Japan [Member] |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |
Total revenue | 2,400 | 1,588 | 4,288
Astellas Agreement [Member] | Development Revenue [Member] | Europe [Member] |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |
Total revenue | 18,503 | 18,523 | 17,487
AstraZeneca Agreements [Member] | China [Member] |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |
Total revenue | 0 | 0 | 0
AstraZeneca Agreements [Member] | License Revenue [Member] | U.S./RoW and China [Member] |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |
Total revenue | 7,946 | 9,933 | 41,059
AstraZeneca Agreements [Member] | Development Revenue [Member] | U.S./RoW and China [Member] |  |  |
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |
Total revenue | $ 104,970 | $ 100,928 | $ 110,677

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- Definition Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 4 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109196051&loc=SL49130543-203045 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109196051&loc=SL49130539-203045 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 5 -URI http://asc.fasb.org/extlink&oid=109196051&loc=SL49130545-203045 + Details
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