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Balance Sheet Components (Tables) | 12 Months Ended
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Dec. 31, 2018
Organization Consolidation And Presentation Of Financial Statements [Abstract] |
Schedule of Cash and Cash Equivalents | Cash and cash equivalents consisted of the following (in thousands):
|  | December 31, |
|  | 2018 |  |  | 2017 |
Cash |  | $ | 38,783 |  |  | $ | 103,716 |
US treasury notes and bills |  |  | 49,934 |  |  |  | — |
Money market funds |  |  | 541 |  |  |  | 569,942 |
Total cash and cash equivalents |  | $ | 89,258 |  |  | $ | 673,658 |
Schedule of Property and Equipment | Property and equipment consisted of the following (in thousands):
|  | December 31, |
|  | 2018 |  |  | 2017 |
Leasehold improvements |  | $ | 101,200 |  |  | $ | 93,758 |
Building shell (Refer to Note 8) |  |  | 53,880 |  |  |  | 53,879 |
Laboratory equipment |  |  | 16,405 |  |  |  | 19,497 |
Machinery |  |  | 8,382 |  |  |  | — |
Computer equipment |  |  | 6,473 |  |  |  | 6,006 |
Furniture and fixtures |  |  | 5,690 |  |  |  | 5,575 |
Construction in progress |  |  | 367 |  |  |  | 10,402 |
Total property and equipment |  | $ | 192,397 |  |  | $ | 189,117 |
Less: accumulated depreciation |  |  | (65,199 | ) |  |  | (59,641 | )
Property and equipment, net |  | $ | 127,198 |  |  | $ | 129,476 |
Summary of Amortized Cost, Gross Unrealized Holding Gains or Losses, and Fair Value of Investments | The Company’s investments consist of available-for-sale debt investments, marketable equity investments, term deposit and certificate of deposit. The amortized cost, gross unrealized holding gains or losses, and fair value of the Company’s investments by major investments type are summarized in the tables below (in thousands):
|  | December 31, 2018 |
|  | Amortized Cost |  |  | Gross Unrealized Holding Gains |  |  | Gross Unrealized Holding Losses |  |  | Fair Value |
US treasury notes and bills |  | $ | 467,296 |  |  | $ | 109 |  |  | $ | (69 | ) |  | $ | 467,336 |
Term deposit |  |  | 80,000 |  |  |  | — |  |  |  | — |  |  |  | 80,000 |
Certificates of deposit |  |  | 30,000 |  |  |  | — |  |  |  | (90 | ) |  |  | 29,910 |
Bond and mutual funds |  |  | 10,464 |  |  |  | 20 |  |  |  | — |  |  |  | 10,484 |
Equity investments |  |  | 125 |  |  |  | 109 |  |  |  | — |  |  |  | 234 |
Total investments |  | $ | 587,885 |  |  | $ | 238 |  |  | $ | (159 | ) |  | $ | 587,964 |
|  | December 31, 2017 |
|  | Amortized Cost |  |  | Gross Unrealized Holding Gains |  |  | Gross Unrealized Holding Losses |  |  | Fair Value |
Corporate bonds |  | $ | 53,985 |  |  | $ | 4 |  |  | $ | (46 | ) |  | $ | 53,943 |
Bond and mutual funds |  |  | 17,249 |  |  |  | 1,153 |  |  |  | — |  |  |  | 18,402 |
Equity investments |  |  | 126 |  |  |  | 95 |  |  |  | — |  |  |  | 221 |
Total investments |  | $ | 71,360 |  |  | $ | 1,252 |  |  | $ | (46 | ) |  | $ | 72,566 |
Summary of Contractual Maturities Available-for-Sale Investments and Term Deposit | The contractual maturities of the available-for-sale investments and term deposit were as follows (in thousands):
|  | December 31, 2018 |
Within one year |  | $ | 532,144 |
After one year through four years |  |  | 45,102 |
Total debt investments |  |  | 577,246 |
Bond and mutual funds |  |  | 10,484 |
Equity investments |  |  | 234 |
Total investments |  | $ | 587,964 |
Schedule of Accrued Liabilities | Accrued liabilities consisted of the following (in thousands):
|  | December 31, |
|  | 2018 |  |  | 2017 |
Preclinical and clinical trial accruals |  | $ | 35,413 |  |  | $ | 32,321 |
Payroll and related accruals |  |  | 21,430 |  |  |  | 18,810 |
Property taxes and other |  |  | 1,095 |  |  |  | 4,201 |
Professional services |  |  | 2,648 |  |  |  | 1,991 |
Other |  |  | 5,537 |  |  |  | 6,458 |
Total accrued liabilities |  | $ | 66,123 |  |  | $ | 63,781 |

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