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Summary of Significant Accounting Policies (Tables) | 12 Months Ended
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Dec. 31, 2018
Accounting Policy [Line Items] |
Schedule of Significant Balance of Accounts Receivable | The Company has not experienced any loss on its deposits of cash and cash equivalents. Included in current assets are significant balances of accounts receivable as follows:
|  | December 31, |
|  | 2018 |  |  | 2017 |
Astellas Pharma Inc. (“Astellas”)—Related party |  |  | 74 | % |  |  | 47 | %
AstraZeneca AB (“AstraZeneca”) |  |  | 26 | % |  |  | 53 | %
Schedule of Adoption of New Revenue Standards | Select line items from the Company’s consolidated statement of operations and balance sheet, which reflect the adoption of the new revenue standards are as follows (in thousands):
|  | Year Ended December 31, 2017 |  |  | Year Ended December 31, 2016 |
|  | As Previously Reported |  |  | New Revenue Standards Adjustment |  |  | As Recast |  |  | As Previously Reported |  |  | New Revenue Standards Adjustment |  |  | As Recast |
Statement of Operations |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License revenue |  | $ | 96,056 |  |  | $ | (86,123 | ) |  | $ | 9,933 |  |  | $ | 137,352 |  |  | $ | (86,745 | ) |  | $ | 50,607 |
Development and other revenue |  |  | 29,612 |  |  |  | 91,451 |  |  |  | 121,063 |  |  |  | 42,225 |  |  |  | 90,357 |  |  |  | 132,582 |
Total revenue |  |  | 125,668 |  |  |  | 5,328 |  |  |  | 130,996 |  |  |  | 179,577 |  |  |  | 3,612 |  |  |  | 183,189 |
Net loss |  |  | (126,203 | ) |  |  | 5,328 |  |  |  | (120,875 | ) |  |  | (61,680 | ) |  |  | 3,612 |  |  |  | (58,068 | )
Net loss per share - basic and diluted |  | $ | (1.73 | ) |  | $ | 0.07 |  |  | $ | (1.66 | ) |  | $ | (0.98 | ) |  | $ | 0.05 |  |  | $ | (0.93 | )
|  |  |  |  |  |  |  |  |  |  |  |  |  | December 31, 2017 |
|  |  |  |  |  |  |  |  |  |  |  |  |  | As Previously Reported |  |  | New Revenue Standards Adjustment |  |  | As Recast |
Balance Sheet |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred revenue, current |  |  |  |  |  |  |  |  |  |  |  |  |  | $ | 7,968 |  |  | $ | 8,702 |  |  | $ | 16,670 |
Deferred revenue, net of current |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 112,231 |  |  |  | 26,010 |  |  |  | 138,241 |
Accumulated deficit |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (595,945 | ) |  |  | (34,712 | ) |  |  | (630,657 | )
Schedule of Impacts to Accumulated Other Comprehensive Loss and Accumulated Deficit Upon Adoption of Guidance | The impacts to the Company’s accumulated other comprehensive loss and accumulated deficit upon adoption of this guidance are as follows (in thousands):
|  | Accumulated Other Comprehensive Loss |  |  | Accumulated Deficit |  |
Balance at December 31, 2017 |  | $ | (1,795 | ) |  | $ | (630,657 | ) | *
Impact of change in accounting principle upon adoption of ASU 2016-01 |  |  | (1,250 | ) |  |  | 1,250 |  |
Opening balance as of January 1, 2018 |  | $ | (3,045 | ) |  | $ | (629,407 | ) |
* | Recast to reflect the adoption of the new revenue standards. See above.
Accumulated Deficit [Member] |
Accounting Policy [Line Items] |
Schedule of Adoption of New Revenue Standards | The adoption of the new revenue standards also resulted in the following changes in the accumulated deficit as of December 31, 2016 and 2015:
|  | As Previously Reported |  |  | New Revenue Standards Adjustment |  |  | As Recast |
Accumulated Deficit |  |  |  |  |  |  |  |  |  |  |  |
As of December 31, 2016 |  | $ | (469,742 | ) |  | $ | (40,040 | ) |  | $ | (509,782 | )
As of December 31, 2015 |  | $ | (408,062 | ) |  | $ | (43,652 | ) |  | $ | (451,714 | )

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