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Collaboration Agreements - Astellas Agreements - Additional Information (Detail) - Astellas Agreement [Member] - USD ($) $ in Millions | 1 Months Ended | 3 Months Ended | 12 Months Ended | 35 Months Ended | 45 Months Ended
--- | --- | --- | --- | --- | ---
Dec. 31, 2018 | Apr. 30, 2006 | Jun. 30, 2005 | Jun. 30, 2018 | Dec. 31, 2018 | Feb. 28, 2009 | Feb. 28, 2009
Japan [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Upfront, non-contingent and time-based payments received |  |  |  |  |  |  | $ 40.1
Development and regulatory approval milestones |  |  | $ 117.5 |  |  |  |
Commercial sales milestone |  |  | $ 15.0 |  |  |  |
Additional consideration based on net sales description |  |  |  |  | Low 20% range |  |
Consideration associated with milestone included in transaction price |  |  |  | $ 15.0 |  |  |
Contract with customer liability, revenue recognized | $ 43.9 |  |  | $ 20.9 |  |  |
Europe [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Upfront, non-contingent and time-based payments received |  |  |  |  |  | $ 320.0 |
Development and regulatory approval milestones |  | $ 425.0 |  |  |  |  |
Additional consideration based on net sales description |  |  |  |  | 0 |  |
Percentage of joint development costs committed to fund |  | 50.00% |  |  |  |  |
Estimated joint development extended service period |  |  |  |  | 2023 |  |

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- Definition The amount of additional consideration based on net sales of product as defined under a collaboration agreement. + References No definition available. + Details
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- Definition Represents the amount of milestone payments related to commercial sales under the collaborative agreement. + References No definition available. + Details
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- Definition Represents the potential amount of milestone payments related to development and regulatory approval under the collaborative agreement. + References No definition available. + Details
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- Definition Estimated joint development extended service period. + References No definition available. + Details
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- Definition Represents the percentage of costs that will be funded by the other party under a collaborative agreement for development costs. + References No definition available. + Details
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- Definition Represents the amount of fixed and determinable non-contingent upfront payments included under the collaborative agreement as arrangement consideration. + References No definition available. + Details
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- Definition Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. + References No definition available. + Details
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- Definition Amount of revenue recognized that was previously included in balance of obligation to transfer good or service to customer for which consideration from customer has been received or is due. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 8 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=109196051&loc=SL49130549-203045 + Details
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- Definition The value of the noncash (or part noncash) consideration given (for example, liability, equity) in a transaction. Noncash is defined as transactions during a period that do not result in cash receipts or cash payments in the period. "Part noncash" refers to that portion of a transaction not resulting in cash receipts or cash payments in the period. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 4 -URI http://asc.fasb.org/extlink&oid=98513485&loc=d3e4313-108586 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 5 -URI http://asc.fasb.org/extlink&oid=98513485&loc=d3e4332-108586 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 3 -URI http://asc.fasb.org/extlink&oid=98513485&loc=d3e4304-108586 + Details
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- Details
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- Details
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- Details
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