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Segment and Geographic Information

12 Months Ended

Dec. 31, 2018

Segment Reporting [Abstract]

Segment and Geographic Information

14. Segment and Geographic Information

The Company has determined that the chief executive officer is the chief operating decision maker (“CODM”). The CODM reviews financial information presented for the Company’s various clinical trial programs as well as results on a consolidated basis. License revenues and development revenues received are not allocated to various programs for purposes of determining a profit measure and resource allocation decisions are made by the CODM based primarily on consolidated results. As such, the Company has concluded that it operates as one segment. Supplemental enterprise-wide information has been presented below.

Geographic Revenues

Geographic revenues, which are based on the bill-to region, are as follows (in thousands):

		Years Ended December 31,
		2018				2017				2016
Europe		$	112,916			$	110,861			$	151,736
Japan (related party)			100,002				20,111				31,323
All other			40				24				130
Total revenue		$	212,958			$	130,996			$	183,189

Geographic Long-Lived Assets

Property and equipment, net by geographic location are as follows (in thousands):

		December 31,
		2018				2017
United States		$	103,539			$	107,228
China			23,659				22,248
Total property and equipment		$	127,198			$	129,476

Customer Concentration

Substantially all of the Company’s revenues to date have been generated from the following collaboration partners that respectively accounted for more than 10% of the Company’s total revenue and accounts receivable:

		Percentage of Revenue												Percentage of Accounts Receivable
		Years Ended December 31,												December 31,
		2018				2017				2016				2018				2017
Astellas—Related party			47	%			15	%			17	%			74	%			47	%
AstraZeneca			53	%			85	%			83	%			26	%			53	%

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- References

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- Definition

The entire disclosure for reporting segments including data and tables. Reportable segments include those that meet any of the following quantitative thresholds a) it's reported revenue, including sales to external customers and intersegment sales or transfers is 10 percent or more of the combined revenue, internal and external, of all operating segments b) the absolute amount of its reported profit or loss is 10 percent or more of the greater, in absolute amount of 1) the combined reported profit of all operating segments that did not report a loss or 2) the combined reported loss of all operating segments that did report a loss c) its assets are 10 percent or more of the combined assets of all operating segments.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-URI http://asc.fasb.org/topic&trid=2134510

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