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Summary of Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2018

Accounting Policy [Line Items]

Schedule of Significant Balance of Accounts Receivable

The Company has not experienced any loss on its deposits of cash and cash equivalents. Included in current assets are significant balances of accounts receivable as follows:

		December 31,
		2018				2017
Astellas Pharma Inc. (“Astellas”)—Related party			74	%			47	%
AstraZeneca AB (“AstraZeneca”)			26	%			53	%

Schedule of Adoption of New Revenue Standards

Select line items from the Company’s consolidated statement of operations and balance sheet, which reflect the adoption of the new revenue standards are as follows (in thousands):

		Year Ended December 31, 2017												Year Ended December 31, 2016
		As Previously Reported				New Revenue Standards Adjustment				As Recast				As Previously Reported				New Revenue Standards Adjustment				As Recast
Statement of Operations
License revenue		$	96,056			$	(86,123	)		$	9,933			$	137,352			$	(86,745	)		$	50,607
Development and other revenue			29,612				91,451				121,063				42,225				90,357				132,582
Total revenue			125,668				5,328				130,996				179,577				3,612				183,189
Net loss			(126,203	)			5,328				(120,875	)			(61,680	)			3,612				(58,068	)
Net loss per share - basic and diluted		$	(1.73	)		$	0.07			$	(1.66	)		$	(0.98	)		$	0.05			$	(0.93	)
														December 31, 2017
														As Previously Reported				New Revenue Standards Adjustment				As Recast
Balance Sheet
Deferred revenue, current														$	7,968			$	8,702			$	16,670
Deferred revenue, net of current															112,231				26,010				138,241
Accumulated deficit															(595,945	)			(34,712	)			(630,657	)

Schedule of Impacts to Accumulated Other Comprehensive Loss and Accumulated Deficit Upon Adoption of Guidance

The impacts to the Company’s accumulated other comprehensive loss and accumulated deficit upon adoption of this guidance are as follows (in thousands):

		Accumulated Other Comprehensive Loss				Accumulated Deficit
Balance at December 31, 2017		$	(1,795	)		$	(630,657	)	*
Impact of change in accounting principle    upon adoption of ASU 2016-01			(1,250	)			1,250
Opening balance as of January 1, 2018		$	(3,045	)		$	(629,407	)

* Recast to reflect the adoption of the new revenue standards. See above.

Accumulated Deficit [Member]

Accounting Policy [Line Items]

Schedule of Adoption of New Revenue Standards

The adoption of the new revenue standards also resulted in the following changes in the accumulated deficit as of December 31, 2016 and 2015:

		As Previously Reported				New Revenue Standards Adjustment				As Recast
Accumulated Deficit
As of December 31, 2016		$	(469,742	)		$	(40,040	)		$	(509,782	)
As of December 31, 2015		$	(408,062	)		$	(43,652	)		$	(451,714	)

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