XML 63 R33.htm IDEA: XBRL DOCUMENT v3.10.0.1
Income Taxes (Tables)
12 Months Ended
Dec. 31, 2018
Income Tax Disclosure [Abstract]  
Schedule of Components of Loss Before Income Taxes

The components of loss before income taxes are as follows (in thousands):

 

 

 

Years Ended December 31,

 

 

 

2018

 

 

2017 *

 

 

2016 *

 

Domestic

 

$

(38,472

)

 

$

(80,735

)

 

$

(25,342

)

Foreign

 

 

(47,644

)

 

 

(39,819

)

 

 

(32,797

)

Loss before provision for income taxes

 

$

(86,116

)

 

$

(120,554

)

 

$

(58,139

)

Schedule of Components of Provision For (Benefit From) Income Taxes

The provision for (benefit from) income taxes consists of the following (in thousands):

 

 

 

Years Ended December 31,

 

 

 

2018

 

 

2017

 

 

2016

 

Current:

 

 

 

 

 

 

 

 

 

 

 

 

Federal

 

$

 

 

$

 

 

$

 

State

 

 

2

 

 

 

2

 

 

 

2

 

Foreign

 

 

302

 

 

 

319

 

 

 

139

 

Total current

 

 

304

 

 

 

321

 

 

 

141

 

Deferred:

 

 

 

 

 

 

 

 

 

 

 

 

Federal

 

 

 

 

 

 

 

 

(212

)

State

 

 

 

 

 

 

 

 

 

Foreign

 

 

 

 

 

 

 

 

 

Total deferred

 

 

 

 

 

 

 

 

(212

)

Total provision for (benefit from) income taxes

 

$

304

 

 

$

321

 

 

$

(71

)

Schedule of Reconciliation Between Statutory Federal Income Tax Rate and Effective Tax Rate

The following is the reconciliation between the statutory federal income tax rate and the Company’s effective tax rate:

 

 

Years Ended December 31,

 

 

2018

 

 

2017

 

 

2016

 

Tax at statutory federal rate

 

21.0

%

 

 

34.0

%

 

 

34.0

%

State tax

 

%

 

 

%

 

 

%

Stock-based compensation expense

 

14.5

%

 

 

18.5

%

 

 

(7.9

)%

Change in deferred tax assets due to rate change

 

%

 

 

43.9

%

 

 

%

Change in valuation allowance due to rate change

 

%

 

 

(43.9

)%

 

 

%

Net operating losses not benefitted

 

(23.2

)%

 

 

(43.8

)%

 

 

(12.9

)%

Foreign net operating losses not benefitted

 

(11.6

)%

 

 

(6.7

)%

 

 

(13.0

)%

Orphan drug credit

 

0.0

%

 

 

(2.0

)%

 

 

%

Other

 

(1.1

)%

 

 

(0.3

)%

 

 

(0.1

)%

Total

 

(0.4

)%

 

 

(0.3

)%

 

 

0.1

%

Schedule of Significant Components of Deferred Tax Assets

Significant components of the Company’s deferred tax assets are as follows (in thousands):

 

 

 

December 31,

 

 

 

2018

 

 

2017

 

Federal and state net operating loss carryforwards

 

$

91,683

 

 

$

71,256

 

Tax credit carryforwards

 

 

45,885

 

 

 

39,488

 

Foreign net operating loss carryforwards

 

 

21,295

 

 

 

15,052

 

Stock-based compensation

 

 

9,281

 

 

 

7,835

 

Lease obligations

 

 

2,511

 

 

 

2,737

 

Reserves and accruals

 

 

6,072

 

 

 

4,851

 

Deferred revenue

 

 

16,454

 

 

 

18,103

 

Fixed assets

 

 

356

 

 

 

 

Other

 

 

450

 

 

 

420

 

Subtotal

 

 

193,987

 

 

 

159,742

 

Less: Valuation allowance

 

 

(193,987

)

 

 

(159,540

)

Net deferred tax assets

 

 

 

 

 

202

 

 

 

 

 

 

 

 

 

 

Fixed assets

 

 

 

 

 

(181

)

Other

 

 

 

 

 

(21

)

Net deferred tax liabilities

 

 

 

 

 

(202

)

Total net deferred tax assets

 

$

 

 

$

 

Schedule of Reconciliation of the Beginning and Ending Amounts of Unrecognized Income Tax Benefits

A reconciliation of the beginning and ending amounts of unrecognized income tax benefits during the three years ended December 31, 2018 is as follows (in thousands):

 

 

 

Federal and State

 

Balance as of December 31, 2015

 

$

24,213

 

Decrease due to prior positions

 

 

(7,109

)

Increase due to current year position

 

 

2,550

 

Balance as of December 31, 2016

 

 

19,654

 

Increase due to prior positions

 

 

303

 

Increase due to current year position

 

 

5,448

 

Decrease due to U.S. tax rate change

 

 

(2,044

)

Balance as of December 31, 2017

 

 

23,361

 

Increase due to prior positions

 

 

379

 

Increase due to current year position

 

 

4,216

 

Balance as of December 31, 2018

 

$

27,956