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Summary of Significant Accounting Policies - Schedule of Adoption of New Revenue Standards (Detail) - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Statement of Operations
Total revenue	$ 212,958	$ 130,996	$ 183,189
Net loss	$ (86,420)	$ (120,875)	$ (58,068)
Net loss per share - basic and diluted	$ (1.03)	$ (1.66)	$ (0.93)
Balance Sheet
Deferred revenue	$ 13,771	$ 16,670
Deferred revenue, net of current	136,109	138,241
Accumulated deficit	(715,827)	(630,657)	$ (509,782)	$ (451,714)
License Revenue [Member]
Statement of Operations
Total revenue	22,269	9,933	50,607
Development and Other Revenue [Member]
Statement of Operations
Total revenue	$ 125,913	121,063	132,582
As Previously Reported [Member] | ASU 2014-09 [Member]
Statement of Operations
Total revenue		125,668	179,577
Net loss		$ (126,203)	$ (61,680)
Net loss per share - basic and diluted		$ (1.73)	$ (0.98)
Balance Sheet
Deferred revenue		$ 7,968
Deferred revenue, net of current		112,231
Accumulated deficit		(595,945)	$ (469,742)	(408,062)
As Previously Reported [Member] | License Revenue [Member] | ASU 2014-09 [Member]
Statement of Operations
Total revenue		96,056	137,352
As Previously Reported [Member] | Development and Other Revenue [Member] | ASU 2014-09 [Member]
Statement of Operations
Total revenue		29,612	42,225
New Revenue Standards Adjustment [Member] | ASU 2014-09 [Member]
Statement of Operations
Total revenue		5,328	3,612
Net loss		$ 5,328	$ 3,612
Net loss per share - basic and diluted		$ 0.07	$ 0.05
Balance Sheet
Deferred revenue		$ 8,702
Deferred revenue, net of current		26,010
Accumulated deficit		(34,712)	$ (40,040)	$ (43,652)
New Revenue Standards Adjustment [Member] | License Revenue [Member] | ASU 2014-09 [Member]
Statement of Operations
Total revenue		(86,123)	(86,745)
New Revenue Standards Adjustment [Member] | Development and Other Revenue [Member] | ASU 2014-09 [Member]
Statement of Operations
Total revenue		$ 91,451	$ 90,357

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