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Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Revenue:
Total revenue	$ 212,958	$ 130,996	$ 183,189
Operating expenses:
Research and development	235,839	196,517	187,206
General and administrative	63,812	51,760	46,025
Total operating expenses	299,651	248,277	233,231
Loss from operations	(86,693)	(117,281)	(50,042)
Interest and other, net
Interest expense	(10,991)	(9,706)	(10,725)
Interest income and other, net	11,568	6,433	2,628
Total interest and other, net	577	(3,273)	(8,097)
Loss before income taxes	(86,116)	(120,554)	(58,139)
Provision for (benefit from) income taxes	304	321	(71)
Net loss	$ (86,420)	$ (120,875)	$ (58,068)
Net loss per share - basic and diluted	$ (1.03)	$ (1.66)	$ (0.93)
Weighted average number of common shares used to calculate net loss per share - basic and diluted	84,062	72,987	62,744
License Revenue [Member]
Revenue:
Total revenue	$ 22,269	$ 9,933	$ 50,607
Development and Other Revenue [Member]
Revenue:
Total revenue	125,913	121,063	132,582
Product Revenue [Member]
Revenue:
Total revenue	$ 64,776	$ 0	$ 0

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