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Collaboration Agreements - Astellas Agreements - Additional Information (Detail) - Astellas Agreement [Member] - USD ($)
$ in Millions
1 Months Ended 3 Months Ended 12 Months Ended 35 Months Ended 45 Months Ended
Dec. 31, 2018
Apr. 30, 2006
Jun. 30, 2005
Jun. 30, 2018
Dec. 31, 2018
Feb. 28, 2009
Feb. 28, 2009
Japan [Member]              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Upfront, non-contingent and time-based payments received             $ 40.1
Development and regulatory approval milestones     $ 117.5        
Commercial sales milestone     $ 15.0        
Additional consideration based on net sales description         Low 20% range    
Consideration associated with milestone included in transaction price       $ 15.0      
Contract with customer liability, revenue recognized $ 43.9     $ 20.9      
Europe [Member]              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Upfront, non-contingent and time-based payments received           $ 320.0  
Development and regulatory approval milestones   $ 425.0          
Additional consideration based on net sales description         0    
Percentage of joint development costs committed to fund   50.00%          
Estimated joint development extended service period         2023