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Balance Sheet Components - Schedule of Property and Equipment (Detail) - USD ($) $ in Thousands	Dec. 31, 2018	Dec. 31, 2017
Property Plant And Equipment [Line Items]
Property and equipment, gross	$ 192,397	$ 189,117
Less: accumulated depreciation	(65,199)	(59,641)
Property and equipment, net	127,198	129,476
Leasehold improvements [Member]
Property Plant And Equipment [Line Items]
Property and equipment, gross	101,200	93,758
Building shell [Member]
Property Plant And Equipment [Line Items]
Property and equipment, gross	53,880	53,879
Laboratory Equipment [Member]
Property Plant And Equipment [Line Items]
Property and equipment, gross	16,405	19,497
Machinery [Member]
Property Plant And Equipment [Line Items]
Property and equipment, gross	8,382	0
Computer Equipment [Member]
Property Plant And Equipment [Line Items]
Property and equipment, gross	6,473	6,006
Furniture and Fixtures [Member]
Property Plant And Equipment [Line Items]
Property and equipment, gross	5,690	5,575
Construction in progress [Member]
Property Plant And Equipment [Line Items]
Property and equipment, gross	$ 367	$ 10,402

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- Definition

Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

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