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Income Taxes - Schedule of Reconciliation Between Statutory Federal Income Tax Rate and Effective Tax Rate (Detail)	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Effective Income Tax Rate Continuing Operations Tax Rate Reconciliation [Abstract]
Tax at statutory federal rate	21.00%	34.00%	34.00%
State tax	0.00%	0.00%	0.00%
Stock-based compensation expense	14.50%	18.50%	(7.90%)
Change in deferred tax assets due to rate change	0.00%	43.90%	0.00%
Change in valuation allowance due to rate change	0.00%	(43.90%)	0.00%
Net operating losses not benefitted	(23.20%)	(43.80%)	(12.90%)
Foreign net operating losses not benefitted	(11.60%)	(6.70%)	(13.00%)
Orphan drug credit	0.00%	(2.00%)	0.00%
Other	(1.10%)	(0.30%)	(0.10%)
Total	(0.40%)	(0.30%)	0.10%

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- Definition

Effective income tax rate reconciliation change in deferred tax assets due to tax cuts and jobs act of 2017.

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Effective income tax rate reconciliation change in valuation allowance due to tax cuts and jobs act of 2017.

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Effective income tax rate reconciliation deduction expense share based compensation cost.

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Effective income tax rate reconciliation net operating losses not benefitted.

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Percentage of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

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Percentage of domestic federal statutory tax rate applicable to pretax income (loss).

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations applicable to statutory income tax expense (benefit) outside of the country of domicile.

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to other adjustments.

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations applicable to state and local income tax expense (benefit), net of federal tax expense (benefit).

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to research tax credit.

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