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Balance Sheet Components (Tables) | 3 Months Ended
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Mar. 31, 2019
Organization Consolidation And Presentation Of Financial Statements [Abstract] |
Schedule of Cash and Cash Equivalents | Cash and cash equivalents consisted of the following (in thousands):
|  | March 31, 2019 |  |  | December 31, 2018 |
Cash |  | $ | 72,278 |  |  | $ | 38,783 |
US treasury notes and bills |  |  | — |  |  |  | 49,934 |
Money market funds |  |  | 9,395 |  |  |  | 541 |
Total cash and cash equivalents |  | $ | 81,673 |  |  | $ | 89,258 |
Summary of Amortized Cost, Gross Unrealized Holding Gains or Losses, and Fair Value of Available-for-Sale Investments | The Company’s investments consist of available-for-sale debt investments, marketable equity investments, a term deposit and a certificate of deposit. The amortized cost, gross unrealized holding gains or losses, and fair value of the Company’s available-for-sale investments by major investments type are summarized in the tables below (in thousands):
|  | March 31, 2019 |
|  | Amortized Cost |  |  | Gross Unrealized Holding Gains |  |  | Gross Unrealized Holding Losses |  |  | Fair Value |
US treasury notes and bills |  | $ | 494,580 |  |  | $ | 516 |  |  | $ | — |  |  | $ | 495,096 |
Term deposit |  |  | 80,000 |  |  |  | — |  |  |  | — |  |  |  | 80,000 |
Certificates of deposit |  |  | 30,000 |  |  |  | — |  |  |  | (4 | ) |  |  | 29,996 |
Bond and mutual funds |  |  | 10,533 |  |  |  | 58 |  |  |  | — |  |  |  | 10,591 |
Equity investments |  |  | 125 |  |  |  | 121 |  |  |  | — |  |  |  | 246 |
Total investments |  | $ | 615,238 |  |  | $ | 695 |  |  | $ | (4 | ) |  | $ | 615,929 |
|  | December 31, 2018 |
|  | Amortized Cost |  |  | Gross Unrealized Holding Gains |  |  | Gross Unrealized Holding Losses |  |  | Fair Value |
US treasury notes and bills |  | $ | 467,296 |  |  | $ | 109 |  |  | $ | (69 | ) |  | $ | 467,336 |
Term deposit |  |  | 80,000 |  |  |  | — |  |  |  | — |  |  |  | 80,000 |
Certificates of deposit |  |  | 30,000 |  |  |  | — |  |  |  | (90 | ) |  |  | 29,910 |
Bond and mutual funds |  |  | 10,464 |  |  |  | 20 |  |  |  | — |  |  |  | 10,484 |
Equity investments |  |  | 125 |  |  |  | 109 |  |  |  | — |  |  |  | 234 |
Total investments |  | $ | 587,885 |  |  | $ | 238 |  |  | $ | (159 | ) |  | $ | 587,964 |
Schedule of Property and Equipment | Property and equipment consisted of the following (in thousands):
|  | March 31, 2019 |  |  | December 31, 2018 |
Leasehold improvements |  | $ | 101,229 |  |  | $ | 101,200 |
Building shell |  |  | — |  |  |  | 53,880 |
Laboratory equipment |  |  | 16,480 |  |  |  | 16,405 |
Machinery |  |  | 8,396 |  |  |  | 8,382 |
Computer equipment |  |  | 6,650 |  |  |  | 6,473 |
Furniture and fixtures |  |  | 5,643 |  |  |  | 5,690 |
Construction in progress |  |  | 607 |  |  |  | 367 |
Total property and equipment |  | $ | 139,005 |  |  | $ | 192,397 |
Less: accumulated depreciation |  |  | (93,177 | ) |  |  | (65,199 | )
Property and equipment, net |  | $ | 45,828 |  |  | $ | 127,198 |
Schedule of Accrued Liabilities | Accrued liabilities consisted of the following (in thousands):
|  | March 31, 2019 |  |  | December 31, 2018 |
Preclinical and clinical trial accruals |  | $ | 41,964 |  |  | $ | 35,413 |
Payroll and related accruals |  |  | 12,368 |  |  |  | 21,430 |
Property taxes and other |  |  | 2,969 |  |  |  | 1,095 |
Professional services |  |  | 3,547 |  |  |  | 2,648 |
Other |  |  | 5,430 |  |  |  | 5,537 |
Total accrued liabilities |  | $ | 66,278 |  |  | $ | 66,123 |

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