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Collaboration Agreements - AstraZeneca Agreements - Additional Information 1 (Detail) - AstraZeneca Agreements [Member] - USD ($) $ in Millions |  |  |  | 3 Months Ended | 12 Months Ended
--- | --- | --- | --- | --- | ---
Dec. 29, 2018 | Dec. 17, 2018 | Jul. 30, 2013 | Mar. 31, 2019 | Dec. 31, 2015
U.S./RoW [Member] |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |
Upfront, non-contingent, non-refundable and time-based payments |  |  | $ 374.0 |  |
Potential milestone payments |  |  | 875.0 |  |
Commercial sales milestone |  |  | 325.0 |  |
U.S./RoW [Member] | Clinical and Development Milestone [Member] |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |
Potential milestone payments |  |  | 65.0 |  |
U.S./RoW [Member] | Regulatory Milestone [Member] |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |
Potential milestone payments |  |  | 325.0 |  |
U.S./RoW [Member] | Deferred Approval Milestone [Member] |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |
Potential milestone payments |  |  | 160.0 |  |
U.S./RoW [Member] | Development Milestones [Member] |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |
Receipt of development milestone payment |  |  |  |  | $ 15.0
China [Member] |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |
Potential milestone payments |  |  | 348.5 |  |
Proceeds from upfront, non-contingent and non-refundable payments |  |  | 28.2 |  |
Commercial sales and other events milestone |  |  | 187.5 |  |
Estimated joint development extended service period |  |  |  | 2024 |
Milestone payment, revenue recognition | $ 6.0 | $ 6.0 |  |  |
China [Member] | Clinical and Development Milestone [Member] |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |
Potential milestone payments |  |  | 15.0 |  |
China [Member] | Regulatory Milestone [Member] |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |
Potential milestone payments |  |  | $ 146.0 |  |

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