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Condensed Consolidated Statements of Operations (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2019
Jun. 30, 2018
Jun. 30, 2019
Jun. 30, 2018
Revenue:        
Total revenue $ 191,566 $ 43,952 $ 215,429 $ 75,876
Operating expenses:        
Research and development 52,008 52,138 102,505 109,112
Selling, general and administrative 26,739 15,055 48,948 30,605
Total operating expenses 78,747 67,193 151,453 139,717
Income (loss) from operations 112,819 (23,241) 63,976 (63,841)
Interest and other, net        
Interest expense (736) (2,750) (1,507) (5,519)
Interest income and other, net 4,125 2,645 8,303 4,717
Total interest and other, net 3,389 (105) 6,796 (802)
Income (loss) before income taxes 116,208 (23,346) 70,772 (64,643)
Provision for income taxes 205 75 180 174
Net income (loss) $ 116,003 $ (23,421) $ 70,592 $ (64,817)
Net income (loss) per share:        
Basic $ 1.34 $ (0.28) $ 0.82 $ (0.78)
Diluted $ 1.26 $ (0.28) $ 0.77 $ (0.78)
Weighted average number of common shares used to calculate net income (loss) per share:        
Basic 86,445 83,750 86,077 83,309
Diluted 91,728 83,750 92,069 83,309
License Revenue [Member]        
Revenue:        
Total revenue $ 150,581 $ 14,323 $ 150,581 $ 14,323
Development and Other Revenue [Member]        
Revenue:        
Total revenue $ 40,985 $ 29,629 $ 64,848 $ 61,553