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Related Party Transactions - Additional Information (Detail) - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018	Dec. 31, 2018
Related Party Transaction [Line Items]
Accounts receivable from related party	$ 4,311,000		$ 4,311,000		$ 47,210,000
Accrued liabilities to related party	781,000		781,000		444,000
Unbilled contract asset	180,000,000		180,000,000		0
Due from Related Parties, Current	127,981,000		127,981,000		0
Net unbilled contract asset	127,981,000		127,981,000		0
Deferred Revenue	52,019,000		52,019,000		0
Europe [Member]
Related Party Transaction [Line Items]
Unbilled contract asset	130,000,000.0		130,000,000.0
Astellas Agreement [Member] | Europe [Member]
Related Party Transaction [Line Items]
Unbilled contract asset	130,000,000.0		130,000,000.0
Deferred Revenue	2,019,000		2,019,000
Astellas [Member] | Europe [Member]
Related Party Transaction [Line Items]
Unbilled contract asset	130,000,000.0		130,000,000.0
Net unbilled contract asset	128,000,000.0		128,000,000.0
Deferred Revenue	2,000,000.0		2,000,000.0
Astellas [Member] | Collaborative Arrangement [Member]
Related Party Transaction [Line Items]
Revenue related to collaboration agreements	134,700,000	$ 20,500,000	139,600,000	$ 25,600,000
Expense related to collaboration agreements	800,000	$ 200,000	1,300,000	$ 700,000
Accounts receivable from related party	4,300,000		4,300,000		47,200,000
Accrued liabilities to related party	$ 800,000		$ 800,000		400,000
Astellas [Member] | Astellas Agreement [Member] | API Shipment [Member]
Related Party Transaction [Line Items]
Accrued liabilities to related party					$ 43,800,000

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